Cancer metastasis: Biological and clinical aspects

被引:12
作者
Duffy, MJ [1 ]
机构
[1] St Vincents Hosp, Dept Nucl Med, Dublin 4, Ireland
关键词
D O I
10.1007/BF02937542
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The main cause of morbidity and mortality in cancer is the formation of distant metastases. While alterations in c-oncogenes, tumour suppressor genes and DNA repair enzymes are the key molecules involved in carcinogenesis, increased expression of proteases, motility factors and altered expression of adhesion molecules are causally involved in metastasis. The proteases mediating metastasis include urokinase plasminogen activator, cathepsin B, D and L and various matrix metalloproteinases. Certain proteases involved in metastasis (e.g., urokinase plasminogen activator) have been shown to be strong and independent prognostic markers for a variety of cancers, Finally, molecules involved in cancer spread are potential targets for new forms of anti-metastatic therapies.
引用
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页码:4 / 8
页数:5
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