Protective effects of Flos lonicera extract on acute liver injury by dimethylnitrosamine-induced in rats

被引：14

作者：

Teng, Yang ^{[2
]}

Sun, Chang Hai ^{[2
]}

Li, Guangzhi ^{[2
]}

Sun, Guangchen ^{[2
]}

Nomachi, Yui ^{[1
]}

Yokota, Junko ^{[1
]}

Yoshioka, Saburo ^{[1
]}

Gang, Jinbo ^{[2
]}

Jiao, Shuqing ^{[2
]}

Zhang, Yu ^{[2
]}

Miyamura, Mitsuhiko ^{[1
]}

机构：

[1] Kochi Med Sch Hosp, Dept Pharm, Nanko Ku, Kochi 7838505, Japan

[2] Jiamusi Univ, Dept Chem & Pharm, Jiamusi 154007, Heilongjiang, Peoples R China

来源：

JOURNAL OF NATURAL MEDICINES | 2010年 / 64卷 / 03期

关键词：

Lonicera japonica; Acute liver injury; Protective effect; Dimethylnitrosamine; INDUCED HEPATIC-FIBROSIS; JAPONICA; ANTIOXIDANT; PROGRESSION; SILYMARIN; COLLAGEN; HPLC;

D O I：

10.1007/s11418-010-0405-x

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

The aim of this study is to investigate effects of Flos lonicera extract (FLE) on acute liver injury model rats which induced by 35 mg/kg dimethylnitrosamine (DMN). Model rats were divided into hepatic injury control group (administrated with water), FLE group (administrated with FLE) and silymarin group (administrated with silymarin which is hepatotherapeutic drug) as positive control. They were examined including ALT, AST, ALP, gamma-GT, ALB and TP levels in serum, and MDA, GPx levels in liver tissue. In addition, pathologic changes, particularly fibrosis, were examined by Azan staining. The results revealed that the ALT, AST, ALP, gamma-GT, MDA GPx and liver fibrosis degree in the LJE group were lower than the silymarin group and control group, ALB and TP were higher than the silymarin group and control group. These results suggested that LJE may help in inhibiting of acute liver injury greater than silymarin.

引用

页码：288 / 294

页数：7

共 36 条

[1]

GENE-EXPRESSION OF TYPE-I, TYPE-III AND TYPE-IV COLLAGENS IN HEPATIC-FIBROSIS INDUCED BY DIMETHYLNITROSAMINE IN THE RAT [J].