Systemic oxytocin treatment modulates α2-adrenoceptors in telencephalic and diencephalic regions of the rat

被引：35

作者：

Díaz-Cabiale, Z

Petersson, M

Narváez, JA

Uvnäs-Moberg, K

Fuxe, K

机构：

[1] Karolinska Inst, Dept Neurosci, BZ Lab, S-17177 Stockholm, Sweden

[2] Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden

[3] Fac Med, Dept Fisiol, Malaga 29080, Spain

来源：

BRAIN RESEARCH | 2000年 / 887卷 / 02期

关键词：

oxytocin; oxytocin receptor; alpha2-adrenoceptor; autoradiography; brain; rat;

D O I：

10.1016/S0006-8993(00)03017-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Systemic subchronic oxytocin treatment significantly and substantially increased the B-max values of the alpha2 agonist [H-3]UK14.304 binding sites in the hypothalamus, the amygdala and the paraventricular thalamic nucleus of the rat as shown by quantitative receptor autoradiography. These results suggest that long-term modulation of autonomic and neuroendocrine functions and emotional behaviours elicited by brain oxytocin may involve enhancement of central alpha2-adrenoceptor function. (C) 2000 Elsevier Science BN. All rights reserved.

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收藏

页码：421 / 425

页数：5

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