Maternal poly I:C exposure during pregnancy regulates TNFα BDNF, and NGF expression in neonatal brain and the maternal-fetal unit of the rat

被引：137

作者：

Gilmore, JH ^{[1
]}

Jarskog, LF ^{[1
]}

Vadlamudi, S ^{[1
]}

机构：

[1] Univ N Carolina, Dept Psychiat, Schizophrenia Res Ctr, Chapel Hill, NC 27599 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2005年 / 159卷 / 1-2期

关键词：

infection; placenta; amniotic fluid; cortex; schizophrenia; animal model;

D O I：

10.1016/j.jneuroim.2004.10.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Maternal infection during pregnancy is associated with increased risk for neurodevelopmental disorders. Polyriboinosinic-polyribocytidilic acid (poly I:C) or saline was administered to rats to model maternal infection; levels of TNFalpha, brain-derived neurotrophic factor (BDNF), and nerve growth factor (NGF) were determined by ELISA. TNFalpha was significantly increased in maternal plasma, placenta, and amniotic fluid, while it was significantly decreased in fetal liver/spleen and neonatal brain. NGF and BDNF were significantly decreased in the placenta and fetal liver/spleen. There was no change in BDNF or NGF in the fetal or neonatal brain. Changes in TNFalpha, BDNF, and NGF after maternal exposure to poly I:C represent a potential mechanism through which maternal infection increases risk for neurodevelopmental disorders. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：106 / 112

页数：7

共 40 条

[1] DIFFERENTIAL-EFFECTS OF INTERLEUKIN-1-BETA AND INTERLEUKIN-2 ON GLIA AND HIPPOCAMPAL-NEURONS IN CULTURE [J].

ARAUJO, DM ;

COTMAN, CW .

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, 1995, 13 (3-4) :201-212

[2] TNFα promotes proliferation of oligodendrocyte progenitors and remyelination [J].

Arnett, HA ;

Mason, J ;

Marino, M ;

Suzuki, K ;

Matsushima, GK ;

Ting, JPY .

NATURE NEUROSCIENCE, 2001, 4 (11) :1116-1122

[3] Determining the fetal inflammatory response in an experimental model of intrauterine inflammation in rats [J].

Bell, MJ ;

Hallenbeck, JM ;

Gallo, V .

PEDIATRIC RESEARCH, 2004, 56 (04) :541-546

[4] Prenatal immune challenge disrupts sensorimotor gating in adult rats:: Implications for the etiopathogenesis of schizophrenia [J].

Borrell, J ;

Vela, JM ;

Arévalo-Martin, A ;

Molina-Holgado, E ;

Guaza, C .

NEUROPSYCHOPHARMACOLOGY, 2002, 26 (02) :204-215

[5] DISTRIBUTION AND CHARACTERIZATION OF TUMOR NECROSIS FACTOR-ALPHA-LIKE IMMUNOREACTIVITY IN THE MURINE CENTRAL-NERVOUS-SYSTEM [J].

BREDER, CD ;

TSUJIMOTO, M ;

TERANO, Y ;

SCOTT, DW ;

SAPER, CB .

JOURNAL OF COMPARATIVE NEUROLOGY, 1993, 337 (04) :543-567

[6] Maternal exposure to respiratory infections and adult schizophrenia spectrum disorders: A prospective birth cohort study [J].

Brown, AS ;

Schaefer, CA ;

Wyatt, RJ ;

Goetz, R ;

Begg, MD ;

Gorman, JM ;

Susser, ES .

SCHIZOPHRENIA BULLETIN, 2000, 26 (02) :287-295

[7] Cytokine induction in fetal rat brains and brain injury in neonatal rats after maternal lipopolysaccharide administration [J].

Cai, ZW ;

Pan, ZL ;

Pang, Y ;

Evans, OB ;

Rhodes, PG .

PEDIATRIC RESEARCH, 2000, 47 (01) :64-72

[8] THE NEUROBIOLOGY OF INFANTILE-AUTISM [J].

CIARANELLO, AL ;

CIARANELLO, RD .

ANNUAL REVIEW OF NEUROSCIENCE, 1995, 18 :101-128

[9] Intrauterine infection, cytokines, and brain damage in the preterm newborn [J].

Dammann, O ;

Leviton, A .

PEDIATRIC RESEARCH, 1997, 42 (01) :1-8

[10] Immunohistochemical expression of tumor necrosis factor alpha in neonatal leukomalacia [J].

Deguchi, K ;

Mizuguchi, M ;

Takashima, S .

PEDIATRIC NEUROLOGY, 1996, 14 (01) :13-16

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