The role of CpG dinucleotides in DNA vaccines

被引：214

作者：

Krieg, AM ^{[1
]}

Yi, AK

Schorr, J

Davis, HL

机构：

[1] Univ Iowa, Dept Internal Med, Interdisciplinary Immunol Program, Iowa City, IA 52242 USA

[2] Vet Affairs Med Ctr, Iowa City, IA 52246 USA

[3] Qiagen Gmbh, Hilden, Germany

[4] Ottawa Civic Hosp, Loeb Res Inst, Ottawa, ON K1Y 4E9, Canada

[5] Univ Ottawa, Ottawa, ON K1Y 4E9, Canada

来源：

TRENDS IN MICROBIOLOGY | 1998年 / 6卷 / 01期

基金：

英国医学研究理事会; 美国国家卫生研究院;

关键词：

D O I：

10.1016/S0966-842X(97)01145-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

DNA vaccines can induce potent humoral and cellular immune responses without any additional adjuvant. Recent studies indicate that unmethylated CpG dinucleotides within DNA vaccines are immune stimulatory and exert an essential endogenous adjuvant activity. These CpG motifs can be added deliberately to DNA or conventional protein vaccines to enhance the Th1 immune response.

引用

页码：23 / 27

页数：5

共 39 条

[1]

Ballas ZK, 1996, J IMMUNOL, V157, P1840

[2]

BERINSTEIN N, 1987, J IMMUNOL, V139, P971

[3] Amplification of antibody production by phosphorothioate oligodeoxynucleotides [J].

Branda, RF ;

Moore, AL ;

Lafayette, AR ;

Mathews, L ;

Hong, R ;

Zon, G ;

Brown, T ;

McCormack, JJ .

JOURNAL OF LABORATORY AND CLINICAL MEDICINE, 1996, 128 (03) :329-338

[4] Bacterial DNA-induced NK cell IFN-gamma production is dependent on macrophage secretion of IL-12 [J].

Chace, JH ;

Hooker, NA ;

Mildenstein, KL ;

Krieg, AM ;

Cowdery, JS .

CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, 1997, 84 (02) :185-193

[5] CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity [J].

Chu, RS ;

Targoni, OS ;

Krieg, AM ;

Lehmann, PV ;

Harding, CV .

JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 186 (10) :1623-1631

[6] DNA-based immunization by in vivo transfection of dendritic cells [J].

Condon, C ;

Watkins, SC ;

Celluzzi, CM ;

Thompson, K ;

Falo, LD .

NATURE MEDICINE, 1996, 2 (10) :1122-1128

[7] Gene vaccination with naked plasmid DNA: Mechanism of CTL priming [J].

Corr, M ;

Lee, DJ ;

Carson, DA ;

Tighe, H .

JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 184 (04) :1555-1560

[8]

Cowdery J, 1996, J IMMUNOL, V156, P4570

[9]

DAVIS HL, 1997, J IMMUNOL, V94, P10833

[10]

DAVIS HL, IN PRESS BLOOD CELL

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