Angiogenic imbalances: the obstetric perspective

被引：37

作者：

Espinoza, Jimmy ^{[1
]}

Uckele, John E. ^{[1
]}

Starr, Robert A. ^{[1
]}

Seubert, David E. ^{[1
]}

Espinoza, Andres F. ^{[1
]}

Berry, Stanley M. ^{[1
]}

机构：

[1] William Beaumont Hosp, Dept Obstet & Gynecol, Royal Oak, MI 48073 USA

来源：

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 2010年 / 203卷 / 01期

关键词：

angiogenic imbalance; endoglin; Mirror syndrome; molar; ovarian hyperstimulation syndrome; preeclampsia; sFlt-1; vascular endothelial growth factor (VEGF); ENDOTHELIAL GROWTH-FACTOR; UTERINE ARTERY DOPPLER; FACTOR RECEPTOR-1 CONCENTRATION; ELEVATED LIVER-ENZYMES; TYROSINE KINASE-1; SOLUBLE ENDOGLIN; MIRROR SYNDROME; MATERNAL SERUM; IN-VITRO; RESTRICTED FETUSES;

D O I：

10.1016/j.ajog.2009.10.891

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Clinical and experimental evidence indicates that angiogenic imbalances may participate in the mechanisms of disease of several pregnancy complications, some of which may be life threatening. This article reviews current evidence in support of this view and the possibility that the fetus may play a central role in these imbalances; it also reviews recent experimental observations that modulation of angiogenic imbalances during pregnancy may have prophylactic and/or therapeutic value.

引用

页码：17.e1 / 17.e8

页数：8

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