Immunotherapy with fragmented Mycobacterium tuberculosis cells increases the effectiveness of chemotherapy against a chronical infection in a murine model of tuberculosis

被引：74

作者：

Cardona, PJ

Arnat, I

Gordillo, S

Arcos, V

Guirado, E

Díaz, J

Vilaplana, C

Tapia, G

Ausina, V

机构：

[1] Univ Autonoma Barcelona, Fdn Inst Invest Ciencies Salut Germans Trias & Pu, Unitat TB Expt, Dept Microbiol, Badalona 08916, Spain

[2] Univ Autonoma Barcelona, Fdn Inst Invest Ciencies Salut Germans Trias & Pu, Dept Pathol, Badalona 08916, Spain

来源：

VACCINE | 2005年 / 23卷 / 11期

关键词：

immunotherapy; chemotherapy; histological analysis;

D O I：

10.1016/j.vaccine.2004.09.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Reduction of colony forming units by rifampicin-isoniazid therapy given 9-17 weeks post-infection was made more pronounced by immunotherapy with a vaccine made of fragmented Mycobacterium tuberculosis cells detoxified and liposomed (RUTI), given on weeks 17, 19 and 21 post-infection, in the murine model of tuberculosis in C57BL/6 and DBA/2 inbred strains. RUTI triggered a Th1/Th2 response, as demonstrated by the production of IgG1, IgG2a and IgG3 antibodies against a wide range of peptides. The histological analysis did not show neither eosinophilia nor necrosis, and granulomatous infiltration was only slightly increased in C57BL/6 mice when RUTI was administered intranasally. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：1393 / 1398

页数：6

共 28 条

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