Dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes: Focus on sitagliptin

被引：130

作者：

Herman, G. A. ^{[1
]}

Stein, P. P. ^{[1
]}

Thornberry, N. A. ^{[1
]}

Wagner, J. A. ^{[1
]}

机构：

[1] Merck Res Labs, Rahway, NJ USA

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2007年 / 81卷 / 05期

关键词：

D O I：

10.1038/sj.clpt.6100167

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Dipeptidyl peptidase-4 ( DPP-4) inhibitors represent a new class of oral antihyperglycemic agents to treat patients with type 2 diabetes. 1 DPP-4 inhibitors improve fasting and postprandial glycemic control without hypoglycemia or weight gain. 1 This article focuses on the physiology, clinical pharmacology, tolerability, and clinical utility of the DPP-4 inhibitor sitagliptin in the management of type 2 diabetes.

引用

收藏

页码：761 / 767

页数：7

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