Garlic enhances circulatory antioxidants during 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis

被引：34

作者：

Balasenthil, S ^{[1
]}

Arivazhagan, S ^{[1
]}

Nagini, S ^{[1
]}

机构：

[1] Annamalai Univ, Fac Sci, Dept Biochem, Annamalainagar 608002, Tamil Nadu, India

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2000年 / 72卷 / 03期

关键词：

oral cancer; garlic; DMBA; lipid peroxidation; antioxidants; chemoprevention;

D O I：

10.1016/S0378-8741(00)00264-6

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The protective effect of garlic (Allium sativum Linn.) on circulatory lipid peroxidation and antioxidants was investigated during 7, 12-dimethylbenz[a]anthracene (DMBA)-induced hamster buccal pouch carcinogenesis in male Syrian hamsters. Enhanced lipid peroxidation in the circulation of tumour-bearing animals was accompanied by a significant decrease in the levels of ascorbic acid, vitamin E, reduced glutathione (GSH), glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase. Administration of garlic extract significantly decreased lipid peroxidation with simultaneous depletion of antioxidants. We speculate that garlic exerts its protective effects by decreasing circulatory lipid peroxides and enhancing antioxidants. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：429 / 433

页数：5

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Balasenthil, S ;

Arivazhagan, S ;

Ramachandran, CR ;

Nagini, S .

CANCER DETECTION AND PREVENTION, 1999, 23 (06) :534-538

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