The effect of routine vaccination on invasive pneumococcal infections in Canadian children, Immunization Monitoring Program, Active 2000-2007

被引：83

作者：

Bettinger, Julie A. ^{[1
,2
]}

Scheifele, David W. ^{[1
,2
]}

Kellner, James D. ^{[3
,4
]}

Halperin, Scott A. ^{[5
,6
]}

Vaudry, Wendy ^{[7
,8
]}

Law, Barbara ^{[9
]}

Tyrrell, Gregory ^{[10
]}

机构：

[1] BC Childrens Hosp, Vaccine Evaluat Ctr, Vancouver, BC V6H 3N1, Canada

[2] Univ British Columbia, Vancouver, BC V5Z 1M9, Canada

[3] Alberta Childrens Prov Gen Hosp, Calgary, AB T2T 5C7, Canada

[4] Univ Calgary, Calgary, AB, Canada

[5] IWK Hlth Ctr, Canadian Ctr Vaccinol, Halifax, NS, Canada

[6] Dalhousie Univ, Halifax, NS, Canada

[7] Stollery Childrens Hosp, Edmonton, AB, Canada

[8] Univ Alberta, Edmonton, AB, Canada

[9] Publ Hlth Agcy Canada, Ctr Immunizat & Resp Infect Dis, Ottawa, ON, Canada

[10] Natl Ctr Streptococcus, Edmonton, AB, Canada

来源：

VACCINE | 2010年 / 28卷 / 09期

关键词：

Conjugate pneumococcal vaccine; STREPTOCOCCUS-PNEUMONIAE INFECTIONS; CONJUGATE VACCINE; UNITED-STATES; ANTIMICROBIAL RESISTANCE; SEROGROUP DISTRIBUTION; SEROTYPE; 19A; DISEASE; EPIDEMIOLOGY; FORMULATION; PREVENTION;

D O I：

10.1016/j.vaccine.2009.12.026

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Active surveillance was conducted by the 12 centers of the Canadian Immunization Monitoring Program, Active from 2000-2007 in children 16 years of age and younger to determine the influence of 7-valent pneumococcal conjugate immunization programs on the prevalence, serotype and antibiotic resistance patterns of invasive pneumococcal disease (IPD) caused by Streptococcus pneumoniae. The absolute number of reported IPD cases decreased 48% (p < 0.01) over the 8-year period and 56% (p < 0.01) in children 0-4 years of age. The absolute number of reported IPD cases caused by serotypes in the conjugate vaccine decreased 87.5% (p < 0.01) overall and 92% (p < 0.01) in children 0-4 years. Although 6 non-vaccine serotypes increased over time, only serotype 19A increased significantly (p < 0.01). Overall, the proportion of penicillin resistant isolates remained unchanged at 17%. Cefotaxime/ceftriaxone resistance remained unchanged at 2% of isolates annually. Universal pneumococcal conjugate infant immunization programs have dramatically decreased cases of invasive pneumococcal disease. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：2130 / 2136

页数：7

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