VLA-4/CD49d downregulated on primed T lymphocytes during interferon-β therapy in multiple sclerosis

被引：50

作者：

Muraro, PA

Leist, T

Bielekova, B

McFarland, HF

机构：

[1] NINDS, Neuroimmunol Branch, NIH, Bethesda, MD 20892 USA

[2] Univ G DAnnunzio, Sch Med, Dept Oncol & Neurosci, I-66013 Chieti, Italy

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2000年 / 111卷 / 1-2期

关键词：

T lymphocytes; multiple sclerosis; interferon-beta; adhesion molecules; VLA-4;

D O I：

10.1016/S0165-5728(00)00362-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Effects on adhesion molecules of immune cells might contribute to the mode of action of interferon-beta (IFN-beta) in multiple sclerosis (MS). We have serially monitored the cell surface expression of integrins CD49d (VLA-4) and CD11a (LFA-I) on fresh T lymphocyte subpopulations from 5 MS patients monthly for 2 months prior to treatment and for 3 months on treatment with IFN-beta 1b. In parallel, we assessed inflammatory disease activity by monthly contrast-enhanced magnetic resonance imaging (MRI). IFN-beta treatment specifically downregulated CD49d expression on CD8+ and CD4+/CD45RO+ 'memory' T lymphocytes and differentially modulated the proportion of CD4+, CD8+ and CD27+ T cells. These effects may play an important role in the reduction of central nervous system cell trafficking and inflammation in MS. (C) 2000 Elsevier Science BN. All rights reserved.

引用

页码：186 / 194

页数：9

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