A randomised, double-blind, controlled trial of the immunogenicity and tolerability of a meningococcal group C conjugate vaccine in young British infants

被引：38

作者：

English, M

MacLennan, JM

Bowen-Morris, JM

Deeks, J

Boardman, M

Brown, K

Smith, S

Buttery, J

Clarke, J

Quataert, S

Lockhart, S

Moxon, ER

机构：

[1] Univ Oxford, John Radcliffe Hosp, Oxford Vaccine Grp, Oxford OX3 9DU, England

[2] Univ Oxford, Inst Hlth Sci, NHS Ctr Stat Med, Imperial Canc Res Fund, Oxford, England

[3] Univ Oxford, John Radcliffe Hosp, Dept Paediat, Oxford OX3 9DU, England

[4] Univ Oxford, John Radcliffe Hosp, Wyeth Lederle Vaccines, Oxford OX3 9DU, England

[5] Wyeth Lederle Vaccines & Pediat, W Henrietta, NY 14586 USA

来源：

VACCINE | 2000年 / 19卷 / 9-10期

关键词：

immunogenicity; tolerability; meningococcal group C vaccine; British infants;

D O I：

10.1016/S0264-410X(00)00241-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A double-blind, randomised, controlled trial was conducted in 248 British infants to assess the immunogenicity and tolerability of three doses of a meningococcal group C/CRM197 conjugate vaccine (Lederle Laboratories, USA) given at 2, 3 and 4 months. Control children received three doses of Hepatitis B vaccine (Engerix B(R); SmithKline Beecham). At 5 months of age, 100% of children receiving the conjugate vaccine had specific immunoglobulin G concentrations > 2.0 mug/ml (n = 116) compared with only 4% of control children (n = 121). Those receiving the conjugate also had 2.5- and 1.6-fold higher geometric mean concentrations of PRP and diphtheria antibodies, respectively. The vaccine was well tolerated. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1232 / 1238

页数：7

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