A stromal cell niche sustains ILC2-mediated type-2 conditioning in adipose tissue

被引：100

作者：

Rana, Batika M. J. ^{[1
]}

Jou, Eric ^{[1
]}

Barlow, Jillian L. ^{[1
]}

Rodriguez-Rodriguez, Noe ^{[1
]}

Walker, Jennifer A. ^{[1
]}

Knox, Claire ^{[1
]}

Jolin, Helen E. ^{[1
]}

Hardman, Clare S. ^{[1
]}

Sivasubramaniam, Meera ^{[1
]}

Szeto, Aydan ^{[1
]}

Cohen, E. Suzanne ^{[2
]}

Scott, Ian C. ^{[2
]}

Sleeman, Matthew A. ^{[2
,7
]}

Chidomere, Chiamaka I. ^{[3
]}

Migoni, Sara Cruz ^{[3
]}

Caamano, Jorge ^{[3
]}

Jorgensen, Helle F. ^{[4
]}

Carobbio, Stefania ^{[5
,6
]}

Vidal-Puig, Antonio ^{[5
,6
]}

McKenzie, Andrew N. J. ^{[1
]}

机构：

[1] MRC, Lab Mol Biol, Cambridge, England

[2] AstraZeneca, Dept Resp Inflammat & Autoimmun, Cambridge, England

[3] Univ Birmingham, Coll Med & Dent Sci, Inst Immunol & Immunotherapy, Birmingham, W Midlands, England

[4] Univ Cambridge, Dept Med, Cardiovasc Med Div, Cambridge, England

[5] Wellcome Trust Sanger Inst, Hinxton, England

[6] Univ Cambridge, Addenbrookes Hosp, Addenbrookes Treatment Ctr, Inst Metab Sci,Metab Res Labs, Cambridge, England

[7] Regeneron Pharmaceut, Tarrytown, NY USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2019年 / 216卷 / 09期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

INNATE LYMPHOID-CELLS; ACCUMULATION; RESPONSES; IMMUNITY; OBESITY; MUSCLE; IL-13; EOSINOPHILS; STIMULATE; ROLES;

D O I：

10.1084/jem.20190689

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Group-2 innate lymphoid cells (ILC2), type-2 cytokines, and eosinophils have all been implicated in sustaining adipose tissue homeostasis. However, the interplay between the stroma and adipose-resident immune cells is less well understood. We identify that white adipose tissue-resident multipotent stromal cells (WAT-MSCs) can act as a reservoir for IL-33, especially after cell stress, but also provide additional signals for sustaining ILC2. Indeed, we demonstrate that WAT-MSCs also support ICAM-1-mediated proliferation and activation of LFA-1-expressing ILC2s. Consequently, ILC2-derived IL-4 and IL-13 feed back to induce eotaxin secretion from WAT-MSCs, supporting eosinophil recruitment. Thus, MSCs provide a niche for multifaceted dialogue with ILC2 to sustain a type-2 immune environment in WAT.

引用

收藏

页码：1999 / 2009

页数：11

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