5-Aminomethylquinoxaline-2,3-diones. Part I: A novel class of AMPA receptor antagonists.

被引：24

作者：

Auberson, YP ^{[1
]}

Bischoff, S ^{[1
]}

Moretti, R ^{[1
]}

Schmutz, M ^{[1
]}

Veenstra, SJ ^{[1
]}

机构：

[1] Novartis Pharma AG, CH-4002 Basel, Switzerland

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 01期

关键词：

D O I：

10.1016/S0960-894X(97)10186-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 5-aminomethylquinoxaline-2,3-diones have been identified as potent and selective AMPA antagonists. Some of these compounds are also active at the glycine-binding site of the NMDA receptors. A number of these novel, water-soluble quinoxaline-2,3-dione derivatives display protective effects in the electroshock-induced convulsion model in mice. (C) 1997 Elsevier Science Ltd. All rights reserved.

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页码：65 / 70

页数：6

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