The glutamate antagonist Riluzole suppresses intracortical facilitation

被引：230

作者：

Liepert, J ^{[1
]}

Schwenkreis, P ^{[1
]}

Tegenthoff, M ^{[1
]}

Malin, JP ^{[1
]}

机构：

[1] Ruhr Univ Bochum, BG Klin Bergmannsheil Univ Klin, Dept Neurol, D-44789 Bochum, Germany

来源：

JOURNAL OF NEURAL TRANSMISSION | 1997年 / 104卷 / 11-12期

关键词：

transcranial magnetic stimulation; riluzole; glutamate; intracortical inhibition; intracortical facilitation; silent period;

D O I：

10.1007/BF01294721

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The effect of the glutamate antagonist riluzole on excitatory and inhibitory phenomena in the human motor system was studied by transcranial magnetic stimulation (TMS) and peripheral electrical nerve stimulation. The motor threshold, the intracortical inhibition and intracortical facilitation as assessed by paired TMS, the cortical and peripheral silent periods, F wave amplitudes and F wave latencies were measured. Riluzole suppressed the intracortical facilitation whereas other parameters remained unchanged, indicating that the neurotransmitter glutamate is mainly involved in facilitatory mechanisms in the motor system.

引用

页码：1207 / 1214

页数：8

共 21 条

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