Immunogenetic correlates for Chlamydia trachomatis-associated tubal infertility

被引:40
作者
Cohen, CR
Gichui, J
Rukaria, R
Sinei, SS
Gaur, LK
Brunham, RC
机构
[1] Univ Washington, Dept Obstet & Gynecol, Seattle, WA 98195 USA
[2] Univ Nairobi, Dept Obstet, Nairobi, Kenya
[3] Univ Nairobi, Dept Gynecol, Nairobi, Kenya
[4] Puget Sound Blood Ctr, Seattle, WA 98104 USA
[5] Univ British Columbia, Ctr Dis Control, Vancouver, BC V5Z 1M9, Canada
关键词
D O I
10.1016/S0029-7844(02)03077-6
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
OBJECTIVE: To understand immunogenetic mechanisms of Chlamydia trachomatis infection and tubal scarring. METHODS: We measured and compared previously significant human leukocyte antigen (HLA) class II DQ alleles, their linked DRB genes, and polymorphisms in selected cytokine genes (tumor necrosis factor alpha-308 promoter; transforming growth factor beta1-10 and -25 codons; interleukin 10-1082, -819, and -592 promoters; interleukin 6-174 promoter; and interferon gamma+874 codon 1) among Kenyan women with confirmed tubal infertility with and without C trachomatis microimmunofluorescence antibody. RESULTS: Two class II alleles, HLA-DR1*1503 and DRB5*0101, were detected less commonly in C trachomatis microimmunofluorescence seropositive women than in C trachomatis microinununofluorescence seronegative women with infertility (0% versus 20%; odds ratio [OR] 0.05; 95% confidence interval [Cl] 0, 0.7, and 6% versus 26%; OR 0.2; 95% CI 0.02,1.0, respectively). These alleles are commonly linked as a haplotype at the DRB locus. This finding could not be explained through linkage disequilibrium. with the other studied FILA or cytokine genes. CONCLUSION: These alleles may lead to an immunologically mediated mechanism of protection against C trachomatis infection and associated tubal damage, or alternatively increase risk for tubal scarring due to another cause.
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页码:438 / 444
页数:7
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