Tumor necrosis factor-alpha and transforming growth factor-beta1 in chronic periapical lesions

被引：42

作者：

Danin, J

Linder, LE

Lundqvist, G

Andersson, L

机构：

[1] Karolinska Inst, Sch Dent, Dept Cariol & Endodont, S-14104 Huddinge, Sweden

[2] Karolinska Inst, Dept Immunol Microbiol Pathol & Infect Dis, S-14104 Huddinge, Sweden

[3] Karolinska Inst, Dept Oral & Maxillofacial Surg, Huddinge, Sweden

[4] Cent Hosp Vasteras, Dept Oral & Maxillofacial Surg, Vasteras, Sweden

[5] Huddinge Univ Hosp, S-14186 Huddinge, Sweden

来源：

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY | 2000年 / 90卷 / 04期

关键词：

D O I：

10.1067/moe.2000.108958

中图分类号：

R78 [口腔科学];

学科分类号：

1003 [口腔医学];

摘要：

Objective. Proinflammatory cytokines are involved in the pathogenesis of periapical lesions. The purpose of this study was to evaluate the presence of the cytokines tumor necrosis factor-alpha (TNF-alpha) and transforming growth factor-beta(1) (TGF-beta(1)) in periapical pathosis and to determine their relationship to the size of the lesions. Study design, One tooth from each of 25 patients was root-end resected, and the periapical lesion was collected, The amounts of TNF-alpha and TCF-beta(1) were assessed by enzyme-linked immunosorbent assay. Results, TGF-beta(1) was detected in 21 of 25 lesions; In samples with scar tissue, no TGF-beta(1) activity was detected. A statistically significant correlation was found between TGF-beta(1) per milligram of tissue and the diameter of the lesions. TNF-alpha was detected in only 2 samples. Conclusions. TGF-beta(1) was present in periapical granulomas and cysts but not in lesions with scar tissue. The correlation between the amount of TGF-beta(1) per milligram of tissue and the size of the lesion was significant.

引用

页码：514 / 517

页数：4

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