Lysosomal cysteine proteases regulate antigen presentation

被引：360

作者：

Honey, K ^{[1
]}

Rudensky, AY

机构：

[1] Univ Washington, Sch Med, Howard Hughes Med Inst, Seattle, WA 98195 USA

[2] Univ Washington, Sch Med, Dept Immunol, Seattle, WA 98195 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2003年 / 3卷 / 06期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nri1110

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Antigen presentation by both classical MHC class II molecules and the non-classical MHC class I-like molecule CD1D requires their entry into the endosomal/lysosomal compartment. Lysosomal cysteine proteases constitute an important subset of the enzymes that are present in this compartment and, here, we discuss the role of these proteases in regulating antigen presentation by both MHC class II and CD1D molecules.

引用

页码：472 / 482

页数：11

共 120 条

[1] Control of antigen presentation by a single protease cleavage site [J].

Antoniou, AN ;

Blackwood, SL ;

Mazzeo, D ;

Watts, C .

IMMUNITY, 2000, 12 (04) :391-398

[2] MHC CLASS-II-ASSOCIATED INVARIANT CHAIN CONTAINS A SORTING SIGNAL FOR ENDOSOMAL COMPARTMENTS [J].

BAKKE, O ;

DOBBERSTEIN, B .

CELL, 1990, 63 (04) :707-716

[3]

BARRETT AJ, 1986, BIOMED BIOCHIM ACTA, V45, P1363

[4]

Beck H, 2001, EUR J IMMUNOL, V31, P3726, DOI 10.1002/1521-4141(200112)31:12<3726::AID-IMMU3726>3.0.CO

[5]

2-O

[6] Differential regulation of cathepsin S and cathepsin L in interferon γ-treated macrophages [J].

Beers, C ;

Honey, K ;

Fink, S ;

Forbush, K ;

Rudensky, A .

JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 197 (02) :169-179

[7] HOW MHC CLASS-II MOLECULES REACH THE ENDOCYTIC PATHWAY [J].

BENAROCH, P ;

YILLA, M ;

RAPOSO, G ;

ITO, K ;

MIWA, K ;

GEUZE, HJ ;

PLOEGH, HL .

EMBO JOURNAL, 1995, 14 (01) :37-49

[8] Impaired hair follicle morphogenesis and cycling with abnormal epidermal differentiation in nackt mice, a cathepsin L-deficient mutation [J].

Benavides, F ;

Starost, MF ;

Flores, M ;

Gimenez-Conti, IB ;

Guénet, JL ;

Conti, CJ .

AMERICAN JOURNAL OF PATHOLOGY, 2002, 161 (02) :693-703

[9] The CD4 T cell-deficient mouse mutation nackt (nkt) involves a deletion in the cathepsin L (Ctsl) gene [J].

Benavides, F ;

Venables, A ;

Klug, HP ;

Glasscock, E ;

Rudensky, A ;

Gómez, M ;

Palenzuela, NM ;

Guénet, JL ;

Richie, ER ;

Conti, CJ .

IMMUNOGENETICS, 2001, 53 (03) :233-242

[10] Autoreactivity by design: Innate B and T lymphocytes [J].

Bendelac, A ;

Bonneville, M ;

Kearney, JF .

NATURE REVIEWS IMMUNOLOGY, 2001, 1 (03) :177-186

← 1 2 3 4 5 6 7 8 9 10 →