Gene targeting and the biology of learning and memory

被引：43

作者：

Silva, AJ ^{[1
]}

Smith, AM ^{[1
]}

Giese, KP ^{[1
]}

机构：

[1] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA

来源：

ANNUAL REVIEW OF GENETICS | 1997年 / 31卷

关键词：

synapses; long-term potentiation; mutants; transgenics; short-term plasticity; hippocampus;

D O I：

10.1146/annurev.genet.31.1.527

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The general goal of genetic studies of learning and memory is to develop and test theories that explain the animal's behavior in neuroanatomical, neurophysiological, cellular, and molecular terms. In this review we describe the role that gene targeting and other transgenic techniques have had in the study of mammalian learning and memory, We focus especially on the hippocampus, a brain structure that is thought to be central to the processing and temporary storage of complex information. We also discuss the main issues that confront this young field, as well as our vision for its future.

引用

页码：527 / 546

页数：20

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