Tec kinases in T cell and mast cell signaling

被引：49

作者：

Felices, Martin ^{[1
]}

Falk, Markus ^{[1
]}

Kosaka, Yoko ^{[1
]}

Berg, Leslie J. ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Dept Pathol, Amherst, MA 01003 USA

来源：

ADVANCES IN IMMUNOLOGY, VOL 93 | 2007年 / 93卷

关键词：

BRUTONS-TYROSINE-KINASE; PLECKSTRIN HOMOLOGY DOMAIN; AFFINITY IGE RECEPTOR; FACTOR-KAPPA-B; FAMILY KINASES; NEGATIVE REGULATION; PHOSPHATIDYLINOSITOL; 3-KINASE; ANTIGEN RECEPTOR; SH3; DOMAIN; SRC FAMILY;

D O I：

10.1016/S0065-2776(06)93004-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The Tec family of tyrosine kinases consists of five members (Itk, Rlk, Tec, Btk, and Bmx) that are expressed predominantly in hematopoietic cells. The exceptions, Tee and Bmx, are also found in endothelial cells. Tee kinases constitute the second largest family of cytoplasmic protein. tyrosine kinases. While B cells express Btk and Tee, and T cells express Itk, Rlk, and Tee, all four of these kinases (Btk, Itk, Rlk, and Tee) can be detected in mast cells. This chapter will focus on the biochemical and cell biological data that have been accumulated regarding Itk, Rlk, Btk, and Tee. In particular, distinctions between the different Tee kinase family members will be highlighted, with a goal of providing insight into the unique functions of each kinase. The known functions of Tec kinases in T cell and mast cell signaling will then be described, with a particular focus on T cell receptor and mast cell Fc epsilon RI signaling pathways.

引用

页码：145 / 184

页数：40

共 208 条

[1] p130Cas couples the tyrosine kinase Bmx/Etk with regulation of the actin cytoskeleton and cell migration [J].

Abassi, YA ;

Rehn, M ;

Ekman, N ;

Alitalo, K ;

Vuori, K .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (37) :35636-35643

[2] Essential role for the p110δ phosphoinositide 3-kinase in the allergic response [J].

Ali, K ;

Bilancio, A ;

Thomas, M ;

Pearce, W ;

Gilfillan, AM ;

Tkaczyk, C ;

Kuehn, N ;

Gray, A ;

Giddings, J ;

Peskett, E ;

Fox, R ;

Bruce, I ;

Walker, C ;

Sawyer, C ;

Okkenhaug, K ;

Finan, P ;

Vanhaesebroeck, B .

NATURE, 2004, 431 (7011) :1007-1011

[3] Positive feedback regulation of PLCγ1/Ca2+ signaling by PKCθ in restimulated T cells via a Tec kinase-dependent pathway [J].

Altman, A ;

Kaminski, S ;

Busuttil, V ;

Droin, N ;

Hu, JR ;

Tadevosyan, Y ;

Hipskind, RA ;

Villalba, M .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2004, 34 (07) :2001-2011

[4] THE HUMAN PROTOONCOGENE PRODUCT P33PIM IS EXPRESSED DURING FETAL HEMATOPOIESIS AND IN DIVERSE LEUKEMIAS [J].

AMSON, R ;

SIGAUX, F ;

PRZEDBORSKI, S ;

FLANDRIN, G ;

GIVOL, D ;

TELERMAN, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (22) :8857-8861

[5] Regulatory intramolecular association in a tyrosine kinase of the Tec family [J].

Andreotti, AH ;

Bunnell, SC ;

Feng, S ;

Berg, LJ ;

Schreiber, SL .

NATURE, 1997, 385 (6611) :93-97

[6] RETRACTED: Mutual regulation of protein-tyrosine phosphatase 20 and protein-tyrosine kinase Tec activities by tyrosine phosphorylation and dephosphorylation (Retracted Article. See vol 285, pg 32678, 2010) [J].

Aoki, N ;

Ueno, S ;

Mano, H ;

Yamasaki, S ;

Shiota, M ;

Miyazaki, H ;

Yamaguchi-Aoki, Y ;

Matsuda, T ;

Ullrich, A .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (11) :10765-10775

[7] Tec kinases Itk and Rlk are required for CD8+ T cell responses to virus infection independent of their role in CD4+ T cell help [J].

Atherly, LO ;

Brehm, MA ;

Welsh, RM ;

Berg, LJ .

JOURNAL OF IMMUNOLOGY, 2006, 176 (03) :1571-1581

[8] Tec regulates platelet activation by GPVI in the absence of Btk [J].

Atkinson, BT ;

Ellmeier, W ;

Watson, SP .

BLOOD, 2003, 102 (10) :3592-3599

[9] CD28 IS ASSOCIATED WITH AND INDUCES THE IMMEDIATE TYROSINE PHOSPHORYLATION AND ACTIVATION OF THE TEC FAMILY KINASE ITK/EMT IN THE HUMAN JURKAT LEUKEMIC T-CELL LINE [J].

AUGUST, A ;

GIBSON, S ;

KAWAKAMI, Y ;

KAWAKAMI, T ;

MILLS, GB ;

DUPONT, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (20) :9347-9351

[10] Src-induced activation of inducible T cell kinase (ITK) requires phosphatidylinositol 3-kinase activity and the Pleckstrin homology domain of inducible T cell kinase [J].

August, A ;

Sadra, A ;

Dupont, B ;

Hanafusa, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (21) :11227-11232

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