Homocysteine associated genomic DNA hypermethylation in patients with chronic alcoholism

被引：113

作者：

Bönsch, D ^{[1
]}

Lenz, B ^{[1
]}

Reulbach, U ^{[1
]}

Kornhuber, J ^{[1
]}

Bleich, S ^{[1
]}

机构：

[1] Univ Erlangen Nurnberg, Dept Psychiat & Psychotherapy, D-91054 Erlangen, Germany

来源：

JOURNAL OF NEURAL TRANSMISSION | 2004年 / 111卷 / 12期

关键词：

homocysteine; alcoholism; global DNA methylation; epigenetic control;

D O I：

10.1007/s00702-004-0232-x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Higher plasma homocysteine concentrations can influence genomic DNA methylation in peripheral blood cells. In the present controlled study we observed a significant increase (10%) of genomic DNA methylation in patients with alcoholism (t = 3.16, df = 158, p = 0.002) which was significantly associated with their elevated homocysteine levels (multiple linear regression, p < 0.001). Since methylation of DNA is an important epigenetic factor in regulation of gene expression these findings may have important implications for a possible subsequent derangement of epigenetic control these patients.

引用

页码：1611 / 1616

页数：6

共 15 条

[1] Methylomics in psychiatry: Modulation of gene-environment interactions may be through DNA methylation [J].

Abdolmaleky, HM ;

Smith, CL ;

Faraone, SV ;

Shafa, R ;

Stone, W ;

Glatt, SJ ;

Tsuang, MT .

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2004, 127B (01) :51-59

[2]

Baylin SB, 1998, ADV CANCER RES, V72, P141

[3] Elevated homocysteine levels in alcohol withdrawal [J].

Bleich, S ;

Degner, D ;

Wiltfang, J ;

Maler, JM ;

Niedmann, P ;

Cohrs, S ;

Mangholz, A ;

Porzig, J ;

Sprung, R ;

Rüther, E ;

Kornhuber, J .

ALCOHOL AND ALCOHOLISM, 2000, 35 (04) :351-354

[4] Oxidative stress and an altered methionine metabolism in alcoholism [J].

Bleich, S ;

Spilker, K ;

Kurth, C ;

Degner, D ;

Quintela-Schneider, M ;

Javaheripour, K ;

Rüther, E ;

Kornhuber, J ;

Wiltfang, J .

NEUROSCIENCE LETTERS, 2000, 293 (03) :171-174

[5] Homocysteine as a neurotoxin in chronic alcoholism [J].

Bleich, S ;

Degner, D ;

Sperling, W ;

Bönsch, D ;

Thürauf, N ;

Kornhuber, J .

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2004, 28 (03) :453-464

[6]

BLEICH S, 2004, IN PRESS ALCOHOL ALC

[7] Increased, homocysteine and S-adenosylhomocysteine concentrations and DNA hypomethylation in vascular disease [J].

Castro, R ;

Rivera, I ;

Struys, EA ;

Jansen, EEW ;

Ravasco, P ;

Camilo, ME ;

Blom, HJ ;

Jakobs, C ;

de Almeida, IT .

CLINICAL CHEMISTRY, 2003, 49 (08) :1292-1296

[8] The methyl donor S-adenosylmethionine inhibits active demethylation of DNA -: A candidate novel mechanism for the pharmacological effects of S-adenosylmethionine [J].

Detich, N ;

Hamm, S ;

Just, G ;

Knox, JD ;

Szyf, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (23) :20812-20820

[9] DNA METHYLATION AND GENE ACTIVITY [J].

DOERFLER, W .

ANNUAL REVIEW OF BIOCHEMISTRY, 1983, 52 :93-124

[10] DNA METHYLATION AND EPIGENETIC DEFECTS IN CARCINOGENESIS [J].

HOLLIDAY, R .

MUTATION RESEARCH, 1987, 181 (02) :215-217

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