Leishmaniasis: drugs in the clinic, resistance and new developments

被引：301

作者：

Ouellette, M ^{[1
]}

Drummelsmith, J

Papadopoulou, B

机构：

[1] CHUL, Ctr Rech, Ctr Rech Infectiol, Quebec City, PQ G1V 4G2, Canada

[2] Univ Laval, Fac Med, Div Microbiol, Quebec City, PQ G1V 4G2, Canada

来源：

DRUG RESISTANCE UPDATES | 2004年 / 7卷 / 4-5期

基金：

英国惠康基金; 加拿大健康研究院;

关键词：

Leishmania; leishmaniasis; kala azar; pentavalent antimonials; stibogluconate; Pentostam; meglumine antimoniate; Glucantime; pentamidine; amphotericin B; miltefosine; fluconazole; ABC transporters;

D O I：

10.1016/j.drup.2004.07.002

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The control of Leishmania infections relies primarily on chemotherapy. The arsenal of drugs available for treating Leishmania infections is limited and includes pentavalent antimonials, pentamidine, amphotericin B, miltefosine, fluconazole and few other drugs at various stages of their development process. In this review, we will discuss the latest results regarding resistance mechanisms to drugs used in the clinic against Leishmania infections. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：257 / 266

页数：10

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