Genomic and functional evidence for an ARID 1A tumor suppressor role

被引：75

作者：

Huang, Jianmin ^{[1
]}

Zhao, Yan-Ling ^{[1
]}

Li, Yu ^{[1
]}

Fletcher, Jonathan A. ^{[1
]}

Xiao, Sheng ^{[1
]}

机构：

[1] Harvard Univ, Dept Pathol, Brigham & Womens Hosp, Sch Med, Boston, MA 02115 USA

来源：

GENES CHROMOSOMES & CANCER | 2007年 / 46卷 / 08期

关键词：

SWI-SNF COMPLEX; SWI/SNF COMPLEXES; BREAST-CANCER; CELL-LINES; DELETION; GENE; P270; ACTIVATION; HSNF5/INI1; MUTATIONS;

D O I：

10.1002/gcc.20459

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

ARIDIA is located in 1p36.11, a region frequently deleted in human cancers. Using a novel method to screen for tumorigenic cDNA sequences, we have identified ARIDIA as a presumptive tumor suppressor gene. The transforming ARIDIA sequence was an antisense cDNA, and was the product of a genomic rearrangement, as corroborated in the primary breast carcinoma from which the cDNA had been obtained. In further screening, we identified a lung adenocarcinoma cell line with a highly localized homozygous genomic deletion involving the 5' end of ARID IA. These studies provide strong evidence that ARIDIA is a tumor suppressor gene. (c) 2007 Wiley-Liss, Inc.

引用

页码：745 / 750

页数：6

共 24 条

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