Y chromosome microdeletion screening in infertile men

被引:44
作者
Maurer, B [1 ]
Simoni, M [1 ]
机构
[1] Univ Munster, Inst Reprod Med, D-48129 Munster, Germany
关键词
Y chromosome; azoospermia; male infertility;
D O I
10.1007/BF03343791
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Molecular analysis of Y-chromosomal microdeletions is routinely performed in the work-up of male infertility, in order to establish a diagnosis and for genetic counseling of the couple, since such microdeletions are transmitted to the male offspring. The review of published data shows that microdeletions are relatively common in patients with azoospermia or severe oligozoospermia, with wide variations in the reported deletion frequency depending mainly on the selection criteria. In general, patients with proximal deletions, involving the AZFa and/or the AZFb region show severe defects of spermatogenesis with a high prevalence of Sertoli cell only syndrome, while deletions of the distal AZFb and of the AZFc region can be compatible with residual spermatogenesis. Microdeletions have been only sporadically found in normozoospermic patients. For the time being the molecular analysis of microdeletions of the Y chromosome is indicated in infertile patients with sperm concentration <5x10(6)/ml and in men undergoing assisted reproduction techniques, since the genetic defect and, most probably, the related infertility problem will be transmitted to the sons.
引用
收藏
页码:664 / 670
页数:7
相关论文
共 51 条
[1]  
ANNEMIEK WN, 1999, HUM REPROD, V14, P2166
[2]   PATHOPHYSIOLOGY AND NATURAL-HISTORY OF MALE-INFERTILITY [J].
BHASIN, S ;
DEKRETSER, DM ;
BAKER, HWG .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1994, 79 (06) :1525-1529
[3]   AZFb deletions predict the absence of spermatozoa with testicular sperm extraction:: preliminary report of a prognostic genetic test [J].
Brandell, RA ;
Mielnik, A ;
Liotta, D ;
Ye, Z ;
Veeck, LL ;
Palermo, GD ;
Schlegel, PN .
HUMAN REPRODUCTION, 1998, 13 (10) :2812-2815
[4]   Y chromosome microdeletion in a father and his four infertile sons [J].
Chang, PL ;
Sauer, MV ;
Brown, S .
HUMAN REPRODUCTION, 1999, 14 (11) :2689-2694
[5]   Human male infertility and Y chromosome deletions:: role of the AZF-candidate genes DAZ, RBM and DFFRY [J].
Ferlin, A ;
Moro, E ;
Garolla, A ;
Foresta, C .
HUMAN REPRODUCTION, 1999, 14 (07) :1710-1716
[6]   High frequency of well-defined Y-chromosome deletions in idiopathic Sertoli cell-only syndrome [J].
Foresta, C ;
Ferlin, A ;
Garolla, A ;
Moro, E ;
Pistorello, M ;
Barbaux, S ;
Rossato, M .
HUMAN REPRODUCTION, 1998, 13 (02) :302-307
[7]   Y chromosome [J].
Foresta, C ;
Ferlin, A ;
Moro, E ;
Scandellari, C .
LANCET, 2000, 355 (9199) :234-235
[8]  
FORESTA C, 1997, J CLIN ENDOCR METAB, V82, P1975
[9]   Submicroscopic deletions in the Y chromosome of infertile men [J].
Girardi, SK ;
Mielnik, A ;
Schlegel, PN .
HUMAN REPRODUCTION, 1997, 12 (08) :1635-1641
[10]   Analysis of Yq microdeletions in infertile males by PGR and DNA hybridization techniques [J].
Grimaldi, P ;
Scarponi, C ;
Rossi, P ;
March, MR ;
Fabbri, A ;
Isidori, A ;
Spera, G ;
Krausz, C ;
Geremia, R .
MOLECULAR HUMAN REPRODUCTION, 1998, 4 (12) :1116-1121