Hypothalamic neuropeptide Y and galanin in overweight rats fed a cafeteria diet

被引：28

作者：

Pedrazzi, P

Cattaneo, L

Valeriani, L

Boschi, S

Cocchi, D

Zoli, M

机构：

[1] Univ Modena, Dipartimento Sci Biomed, Sez Fisiol, I-41100 Modena, Italy

[2] Univ Milan, Dept Pharmacol, Milan, Italy

[3] Univ Brescia, Dept Biomed Sci & Biotechnol, Brescia, Italy

[4] Interuniv Ctr Study Aging, Milan, Italy

来源：

PEPTIDES | 1998年 / 19卷 / 01期

关键词：

hypothalamus; neuropeptide Y; galanin; mRNA; immunocytochemistry; computer-assisted image analysis; obesity; cafeteria diet; rat;

D O I：

10.1016/S0196-9781(97)00258-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We evaluated neuropeptide Y (NPY) and galanin (GAL) immunoreactivity (IR) and mRNA in the paraventricular and arcuate nucleus, respectively, in rats that became overweight (Ov) or not (NOv) when fed a cafeteria diet. After 2 months of diet, NOv rats showed a significant increase in NPY IR, whereas Ov rats showed a significant increase in GAL mRNA levels. None of these changes was present in rats overfed for 6.5 months. These differential changes in hypothalamic GAL and NPY transmissions may contribute to the different susceptibility of the two rat subpopulations to the weight-promoting effects of the hypercaloric diet. (C) 1998 Elsevier Science Inc.

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页码：157 / 165

页数：9

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