Synthesis of a highly fluorinated fatty acid analog

被引：7

作者：

Buchanan, GW ^{[1
]}

Smits, R ^{[1
]}

Munteanu, E ^{[1
]}

机构：

[1] Carleton Univ, Ottawa Carleton Chem Inst, Dept Chem, Ottawa, ON K15 5B6, Canada

来源：

JOURNAL OF FLUORINE CHEMISTRY | 2003年 / 119卷 / 02期

基金：

加拿大自然科学与工程研究理事会;

关键词：

heptadecafluoro-oleic acid analog;

D O I：

10.1016/S0022-1139(02)00254-3

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A five-step synthesis of Z-11,11,12,12,13,13,14,14,15,15,16,16,17,17,18,18,18-heptadecafluoro-octadec-8-enoic acid is reported, starting from 1,8-octanediol and 1,1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8-heptadecafluoro-10-iododecane. The key step is a Wittig reaction to form the C8-C9 double bond with a Z:E isomeric ratio of 10:1. The route should be generally applicable to the synthesis of highly fluorinated monounsaturated fatty acids. (C) 2002 Published by Elsevier Science B.V.

引用

页码：207 / 209

页数：3

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