Toll like receptor 4 in atherosclerosis and plaque destabilization

被引：139

作者：

den Dekker, Wijnand K. ^{[1
]}

Cheng, Caroline ^{[1
]}

Pasterkamp, Gerard ^{[2
]}

Duckers, Hencricus J. ^{[1
]}

机构：

[1] Erasmus MC, Thoraxctr, Mol Cardiol Lab, Rotterdam, Netherlands

[2] Univ Med Ctr Utrecht, Expt Cardiol Lab, Utrecht, Netherlands

来源：

ATHEROSCLEROSIS | 2010年 / 209卷 / 02期

关键词：

Atherosclerosis; Toll like receptor 4; Vulnerable plaque; Immune system; SMOOTH-MUSCLE-CELLS; ACUTE MYOCARDIAL-INFARCTION; ACUTE CORONARY SYNDROME; MURINE MAST-CELLS; REDUCES ATHEROSCLEROSIS; SIGNAL-TRANSDUCTION; APOLIPOPROTEIN-E; DENDRITIC CELLS; DROSOPHILA TOLL; HUMAN MONOCYTES;

D O I：

10.1016/j.atherosclerosis.2009.09.075

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

The immune system plays a pivotal role in initiation and progression of atherosclerosis. Monocytes and T-lymphocytes are the first cells to enter the damaged endothelium. Differentiation of monocytes into macrophages and ingestion of lipids by these macrophages turning them into foam cells is a crucial step in the development of a fatty streak, the first sign of atherosclerosis. In recent years there has been accumulating evidence for the involvement of Toll like receptor 4, a pattern recognition receptor of the innate immune system, in the pathogenesis of atherosclerosis. Different cell types present in the atherosclerotic plaque express TLR4 and several pro-atherogenic ligands have been shown to activate TLR4. The innate immune system and the TLR signaling cascade may play an important role not only in the pathogenesis of atherosclerosis, but also in plaque destabilization. In this review, we discuss the role of TLR4 in the pathogenesis of atherosclerosis and vulnerable plaque development. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

引用

页码：314 / 320

页数：7

共 60 条

[1]

Toll-like receptors: critical proteins linking innate and acquired immunity [J].

Akira, S ;

Takeda, K ;

Kaisho, T .

NATURE IMMUNOLOGY, 2001, 2 (08) :675-680

[2]

AMEZIANE N, 2003, ARTERIOSCLER THROMB, V23, pPE61

[3]

TLR4 mutations are associated with endotoxin hyporesponsiveness in humans [J].

Arbour, NC ;

Lorenz, E ;

Schutte, BC ;

Zabner, J ;

Kline, JN ;

Jones, M ;

Frees, K ;

Watt, JL ;

Schwartz, DA .

NATURE GENETICS, 2000, 25 (02) :187-+

[4]

Absence of regulated splicing of fibronectin EDA exon reduces atherosclerosis in mice [J].

Babaev, Vladimir R. ;

Porro, Fabiola ;

Linton, MacRae E. ;

Fazio, Sergio ;

Baralle, Francisco E. ;

Muro, Andres F. .

ATHEROSCLEROSIS, 2008, 197 (02) :534-540

[5]

BERBERIAN PA, 1990, AM J PATHOL, V136, P71

[6]

Oxidized phospholipids negatively regulate dendritic cell maturation induced by TLRs and CD40 [J].

Blüml, S ;

Kirchberger, S ;

Bochkov, VN ;

Krönke, G ;

Stuhlmeier, K ;

Majdic, O ;

Zlabinger, GJ ;

Knapp, W ;

Binder, BR ;

Stöckl, J ;

Leitinger, N .

JOURNAL OF IMMUNOLOGY, 2005, 175 (01) :501-508

[7]

S-100 POSITIVE CELLS IN HUMAN ARTERIAL INTIMA AND IN ATHEROSCLEROTIC LESIONS [J].

BOBRYSHEV, YV ;

LORD, RSA .

CARDIOVASCULAR RESEARCH, 1995, 29 (05) :689-696

[8]

Variants of toll-like receptor 4 modify the efficacy of statin therapy and the risk of cardiovascular events [J].

Boekholdt, SM ;

Agema, WRP ;

Peters, RJG ;

Zwinderman, AH ;

van der Wall, EE ;

Reitsma, PH ;

Kastelein, JJP ;

Jukema, JW .

CIRCULATION, 2003, 107 (19) :2416-2421

[9]

Perivascular mast cells promote atherogenesis and induce plaque destabilization in apolipoprotein E-deficient mice [J].

Bot, Ilze ;

de Jager, Saskia C. A. ;

Zernecke, Alma ;

Lindstedt, Ken A. ;

van Berkel, Theo J. C. ;

Weber, Christian ;

Biessen, Erik A. L. .

CIRCULATION, 2007, 115 (19) :2516-2525

[10]

Pioglitazone Inhibits Toll-Like Receptor Expression and Activity in Human Monocytes and db/db Mice [J].

Dasu, Mohan R. ;

Park, Samuel ;

Devaraj, Sridevi ;

Jialal, Ishwarlal .

ENDOCRINOLOGY, 2009, 150 (08) :3457-3464

← 1 2 3 4 5 6 →