A combined linkage-physical map of the human genome

被引：192

作者：

Kong, X

Murphy, K

Raj, T

He, C

White, PS

Matise, TC

机构：

[1] Rutgers State Univ, Dept Genet, Piscataway, NJ 08840 USA

[2] Childrens Hosp Philadelphia, Div Oncol, Philadelphia, PA 19104 USA

来源：

AMERICAN JOURNAL OF HUMAN GENETICS | 2004年 / 75卷 / 06期

关键词：

D O I：

10.1086/426405

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We have constructed de novo a high-resolution genetic map that includes the largest set, to our knowledge, of polymorphic markers (N = 14,759) for which genotype data are publicly available; that combines genotype data from both the Centre d'Etude du Polymorphisme Humain (CEPH) and deCODE pedigrees; that incorporates single-nucleotide polymorphisms; and that also incorporates sequence-based positional information. The position of all markers on our map is corroborated by both genomic sequence and recombination-based data. This specific combination of features maximizes marker inclusion, coverage, and resolution, making this map uniquely suitable as a comprehensive resource for determining genetic map information (order and distances) for any large set of polymorphic markers.

引用

页码：1143 / 1148

页数：6

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