Cephalostatin support studies 12. The first synthesis of the aglycone of the potent anti-tumor steroidal saponin OSW-1

被引：76

作者：

Guo, CX ^{[1
]}

Fuchs, PL ^{[1
]}

机构：

[1] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 10期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4039(97)10814-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The protected aglycone (21e-beta) of the potent anti-tumor agent OSW-1 (1) was synthesized in 9 steps from 5-androsten-3 beta-ol-17-one (10) in 55% overall yield. Key reactions involve ene installation of the side chain, regio and stereoselective dihydroxylation and diastereoselective reduction of the C16 ketone. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：1099 / 1102

页数：4

共 20 条

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