IMGT/HLA and IMGT/MHC: sequence databases for the study of the major histocompatibility complex

被引:247
作者
Robinson, J
Waller, MJ
Parham, P
de Groot, N
Bontrop, R
Kennedy, LJ
Stoehr, P
Marsh, SGE
机构
[1] Royal Free Hosp, Anthony Nolan Res Inst, London NW3 2QG, England
[2] Royal Free Hosp, Dept Haematol, London NW3 2QG, England
[3] Stanford Univ, Dept Biol Struct, Stanford, CA 94305 USA
[4] Stanford Univ, Dept Microbiol & Immunol, Stanford, CA 94305 USA
[5] Biomed Primate Res Ctr, Rijswijk, Netherlands
[6] Univ Manchester, Ctr Integrated Genom Med Res, Manchester M13 9PT, Lancs, England
[7] EBI, EMBL Outstn, Cambridge CB10 1SD, England
关键词
D O I
10.1093/nar/GKG070
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The IMGT/HLA database (http://www.ebi.ac.uk/imgt/hla) has provided a centralized repository for the sequences of the alleles named by the WHO Nomenclature Committee for Factors of the HLA System for the past four years. Since its initial release the database has grown and is the primary source of information for the study of sequences of the human major histocompatibilty complex. The initial release of the database contained a limited number of tools. As a result of feedback from our users and developments in HLA we have been able to provide new tools and facilities. The HLA sequences have also been extended to include intron sequences and the 3' and 5' untranslated regions in the alignments and also the inclusion of new genes such as MICA. The IMGT/MHC database (http://www.ebi.ac.uk/imgt/mhc) was released in March 2002 to provide a similar resource for other species. The first release of IMGT/MHC contains the sequences of non-human primates (apes, new and old world monkeys), canines and feline sequences. Further species will be added shortly and the database aims to become the primary source of MHC data for non-human sequences.
引用
收藏
页码:311 / 314
页数:4
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