Novel thermoresponsive and pH-responsive aggregates from self-assembly of triblock copolymer PSMA-b-PNIPAAm-b-PSMA

被引：44

作者：

Zhou, Junfeng ^{[1
]}

Wang, Li ^{[1
]}

Yang, Qiang ^{[1
]}

Liu, Qingquan ^{[1
]}

Yu, Haojie ^{[1
]}

Zhao, Zhenrong ^{[1
]}

机构：

[1] Zhejiang Univ, State Key Lab Chem Engn, Hangzhou 310027, Peoples R China

来源：

JOURNAL OF PHYSICAL CHEMISTRY B | 2007年 / 111卷 / 20期

关键词：

D O I：

10.1021/jp070480h

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A series of novel triblock copolymers of poly(stearyl methacrylate)-b-poly(N-isopropylacrylamide)-b-poly(stearyl methacrylate) (PSMA-b-PNIPAAm-b-PSMA) with different molecular weights was synthesized through carboxyl-terminated trithiocarbonates as a highly efficient RAFT agent via reversible addition-fragmentation chain transfer (RAFT) polymerization. The resultant polymers were characterized by H-1 NMR, FT-IR spectroscopy, and GPC. By varying the organic solvent used in the self-assembly procedure and adjusting the copolymer composition, multiple morphologies ranging from vesicles and core-shell spherical aggregates with different dimensions to pearl-necklace-like aggregates were obtained. The aggregates showed thermoresponsive and pH-responsive properties through the lower critical solution temperature (LCST) of PNIPAAm and the two carboxyl end groups of the copolymer.

引用

页码：5573 / 5580

页数：8

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