Targeted therapies for gastric cancer: failures and hopes from clinical trials

被引：117

作者：

Apicella, Maria ^{[1
]}

Corso, Simona ^{[1
]}

Giordano, Silvia ^{[1
]}

机构：

[1] Univ Torino, Dept Oncol, Candiolo Canc Inst FPO, IRCCS, Turin, Italy

来源：

ONCOTARGET | 2017年 / 8卷 / 34期

关键词：

gastric cancer clinical trials; targeted therapies; HER2; tyrosine kinase receptors; immunotherapy; GROWTH-FACTOR RECEPTOR; HER2 GENE AMPLIFICATION; IN-SITU HYBRIDIZATION; LAPATINIB PLUS CAPECITABINE; PHASE-II TRIAL; 1ST-LINE THERAPY; INTESTINAL-TYPE; DOUBLE-BLIND; PROGNOSTIC-SIGNIFICANCE; ADJUVANT IMMUNOTHERAPY;

D O I：

10.18632/oncotarget.14825

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Gastric cancer is the third leading cause of cancer mortality worldwide. As surgery is the only curative treatment strategy and conventional chemotherapy has shown limited efficacy - with a median overall survival of 10 months-new treatments are urgently needed. Trastuzumab and Ramucirumab (targeting HER2 and VEGFR2, respectively) are the only targeted therapies approved so far. Indeed, most Phase III clinical trials evaluating molecular drugs in gastric cancer failed. This review will retrace the relevant clinical trials with molecular therapies performed in gastric cancer patients, discussing the possible reasons for their failure and indicating new perspective for a real improvement of the treatment of this disease.

引用

页码：57654 / 57669

页数：16

共 96 条

[1]

PD-L1 expression and outcome of advanced melanoma patients treated with anti-PD-1/PD-L1 agents: a meta-analysis [J].

Abdel-Rahman, Omar .

IMMUNOTHERAPY, 2016, 8 (09) :1081-1090

[2]

Al-Batran S, 2014, ANN ONCOL, V25

[3]

[Anonymous], J CLIN ONCOL S

[4]

[Anonymous], 2015, J CLIN ONCOL S

[5]

Approaching heterogeneity of human epidermal growth factor receptor 2 in surgical specimens of gastric cancer [J].

Asioli, Sofia ;

Maletta, Francesca ;

di Cantogno, Ludovica Verdun ;

Satolli, Maria A. ;

Schena, Marina ;

Pecchioni, Carla ;

Botta, Cristina ;

Chiusa, Luigi ;

Molinaro, Luca ;

Conti, Luca ;

Viale, Giuseppe ;

Ingravallo, Giuseppe ;

Maiorano, Eugenio ;

Sapino, Anna .

HUMAN PATHOLOGY, 2012, 43 (11) :2070-2079

[6]

Bang YJ, 2010, LANCET, V376, P1302

[7]

Trastuzumab-DM1 is highly effective in preclinical models of HER2-positive gastric cancer [J].

Barok, Mark ;

Tanner, Minna ;

Koninki, Katri ;

Isola, Jorma .

CANCER LETTERS, 2011, 306 (02) :171-179

[8]

Association of ERBB2 gene status with histopathological parameters and disease-specific survival in gastric carcinoma patients [J].

Barros-Silva, J. D. ;

Leitao, D. ;

Afonso, L. ;

Vieira, J. ;

Dinis-Ribeiro, M. ;

Fragoso, M. ;

Bento, M. J. ;

Santos, L. ;

Ferreira, P. ;

Rego, S. ;

Brandao, C. ;

Carneiro, F. ;

Lopes, C. ;

Schmitt, F. ;

Teixeira, M. R. .

BRITISH JOURNAL OF CANCER, 2009, 100 (03) :487-493

[9]

Pertuzumab plus Trastuzumab plus Docetaxel for Metastatic Breast Cancer [J].

Baselga, Jose ;

Cortes, Javier ;

Kim, Sung-Bae ;

Im, Seock-Ah ;

Hegg, Roberto ;

Im, Young-Hyuck ;

Roman, Laslo ;

Pedrini, Jose Luiz ;

Pienkowski, Tadeusz ;

Knott, Adam ;

Clark, Emma ;

Benyunes, Mark C. ;

Ross, Graham ;

Swain, Sandra M. .

NEW ENGLAND JOURNAL OF MEDICINE, 2012, 366 (02) :109-119

[10]

Comprehensive molecular characterization of gastric adenocarcinoma [J].

Bass, Adam J. ;

Thorsson, Vesteinn ;

Shmulevich, Ilya ;

Reynolds, Sheila M. ;

Miller, Michael ;

Bernard, Brady ;

Hinoue, Toshinori ;

Laird, Peter W. ;

Curtis, Christina ;

Shen, Hui ;

Weisenberger, Daniel J. ;

Schultz, Nikolaus ;

Shen, Ronglai ;

Weinhold, Nils ;

Keiser, David P. ;

Bowlby, Reanne ;

Sipahimalani, Payal ;

Cherniack, Andrew D. ;

Getz, Gad ;

Liu, Yingchun ;

Noble, Michael S. ;

Pedamallu, Chandra ;

Sougnez, Carrie ;

Taylor-Weiner, Amaro ;

Akbani, Rehan ;

Lee, Ju-Seog ;

Liu, Wenbin ;

Mills, Gordon B. ;

Yang, Da ;

Zhang, Wei ;

Pantazi, Angeliki ;

Parfenov, Michael ;

Gulley, Margaret ;

Piazuelo, M. Blanca ;

Schneider, Barbara G. ;

Kim, Jihun ;

Boussioutas, Alex ;

Sheth, Margi ;

Demchok, John A. ;

Rabkin, Charles S. ;

Willis, Joseph E. ;

Ng, Sam ;

Garman, Katherine ;

Beer, David G. ;

Pennathur, Arjun ;

Raphael, Benjamin J. ;

Wu, Hsin-Ta ;

Odze, Robert ;

Kim, Hark K. ;

Bowen, Jay .

NATURE, 2014, 513 (7517) :202-209

← 1 2 3 4 5 6 7 8 9 10 →