SCL/Tal-1 transcription factor acts downstream of cloche to specify hematopoietic and vascular progenitors in zebrafish

被引：272

作者：

Liao, EC

Paw, BH

Oates, AC

Pratt, SJ

Postlethwait, JH

Zon, LI ^{[1
]}

机构：

[1] Harvard Univ, Childrens Hosp, Sch Med, Dept Pediat,Div Hematol Oncol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Howard Hughes Med Inst, Boston, MA 02115 USA

[3] MIT, Div Hlth Sci & Technol, Cambridge, MA 02139 USA

[4] PO Royal Melbourne Hosp, Ludwig Inst Canc Res, Melbourne, Vic, Australia

[5] Univ Oregon, Inst Neurosci, Eugene, OR 97403 USA

来源：

GENES & DEVELOPMENT | 1998年 / 12卷 / 05期

关键词：

SCL/Tal-1; clo; zebrafish; hematopoiesis; vasculogenesis;

D O I：

10.1101/gad.12.5.621

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

SCL/Tal-1 is a transcription factor necessary for hematopoietic stem cell differentiation. Although SCL is also expressed in endothelial and neural progenitors, SCL function in these cells remains unknown. In the zebrafish mutant cloche (do), SCL expression is nearly abolished in hematopoietic and vascular tissues. Correspondingly, it was shown previously that do fails to differentiate blood and angioblasts. Genetic analysis demonstrates that the do mutation is not linked to the SCL locus. forced expression of SCL in do embryos rescues the blood and vascular defects, suggesting that SCL acts downstream of do to specify hematopoietic and vascular differentiation.

引用

页码：621 / 626

页数：6

共 38 条

[1] CHROMOSOMAL TRANSLOCATION IN A HUMAN-LEUKEMIC STEM-CELL LINE DISRUPTS THE T-CELL ANTIGEN RECEPTOR DELTA-CHAIN DIVERSITY REGION AND RESULTS IN A PREVIOUSLY UNREPORTED FUSION TRANSCRIPT [J].