Principles, implementation, and application of biology-oriented synthesis (BIOS)

被引：39

作者：

Wilk, Wolfram ^{[1
,2
]}

Zimmermann, Tobias J. ^{[1
,2
]}

Kaiser, Markus ^{[3
]}

Waldmann, Herbert ^{[1
,2
]}

机构：

[1] Max Planck Inst Mol Physiol, Abt Chem Biol, D-44227 Dortmund, Germany

[2] Tech Univ Dortmund, Fak Chem, D-44227 Dortmund, Germany

[3] Max Planck Gesell, Chem Genom Ctr, D-44227 Dortmund, Germany

来源：

BIOLOGICAL CHEMISTRY | 2010年 / 391卷 / 05期

关键词：

biology-oriented synthesis; chemical biology; cheminformatics; compound libraries; natural products; SOLID-PHASE SYNTHESIS; COMPOUND LIBRARY DEVELOPMENT; SIMILARITY CLUSTERING PSSC; TYROSINE KINASE INHIBITORS; NATURAL-PRODUCT STRUCTURE; CHEMICAL SPACE; PHOSPHATASE INHIBITORS; IDENTIFICATION; DISCOVERY; COLLECTION;

D O I：

10.1515/BC.2010.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Biology-oriented synthesis (BIOS) represents an alternative approach for the generation of compound collections for biological applications. In BIOS, biologically relevant and prevalidated scaffold structures, such as core structures of natural products or known drugs, are employed as scaffolds for the generation of compound collections with focused diversity. In this review, we discuss the underlying concept of the BIOS approach, and its practical implementation in library design and synthesis. To highlight its relevance for chemical biology applications, we finally present examples in which compound collections generated under the BIOS principle have been used to elucidate biological questions.

引用

页码：491 / 497

页数：7

共 49 条

[1] Exploring new chemical space by stereocontrolled diversity-oriented synthesis [J].

Arya, P ;

Joseph, R ;

Gan, ZH ;

Rakic, B .

CHEMISTRY & BIOLOGY, 2005, 12 (02) :163-180

[2] Design of compound libraries based on natural product scaffolds and protein structure similarity clustering (PSSC) [J].

Balamurugan, R ;

Dekker, FJ ;

Waldmann, H .

MOLECULAR BIOSYSTEMS, 2005, 1 (01) :36-45

[3] Natural product-guided synthesis of a spiroacetal collection reveals modulators of tubulin cytoskeleton integrity [J].

Barun, O ;

Kumar, K ;

Sommer, S ;

Langerak, A ;

Mayer, TU ;

Müller, O ;

Waldmann, H .

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2005, 2005 (22) :4773-4788

[4] Total synthesis and biological evaluation of the protein phosphatase 2A inhibitor cytostatin and analogues [J].

Bialy, L ;

Waldmann, H .

CHEMISTRY-A EUROPEAN JOURNAL, 2004, 10 (11) :2759-2780

[5]

Bohacek RS, 1996, MED RES REV, V16, P3, DOI 10.1002/(SICI)1098-1128(199601)16:1<3::AID-MED1>3.0.CO

[6]

2-6

[7] Solid-phase synthesis of dysidiolide-derived protein phosphatase inhibitors [J].

Brohm, D ;

Philippe, N ;

Metzger, S ;

Bhargava, A ;

Müller, O ;

Lieb, F ;

Waldmann, H .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (44) :13171-13178

[8]

Brohm D, 2002, ANGEW CHEM INT EDIT, V41, P307, DOI 10.1002/1521-3773(20020118)41:2<307::AID-ANIE307>3.0.CO

[9]

2-1

[10] A planning strategy for diversity-oriented synthesis [J].

Burke, MD ;

Schreiber, SL .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2004, 43 (01) :46-58

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