Immunomodulatory effects of zinc and DHEA on the Th-1 immune response in rats infected with Trypanosoma cruzi

被引：22

作者：

Brazao, Vania ^{[1
]}

Santello, Fabricia Helena ^{[1
]}

Caetano, Leony Cristina ^{[1
]}

Filipin, Marina Del Vecchio ^{[1
]}

Alonso Toldo, Miriam Paula ^{[1
]}

do Prado, Jose Clovis, Jr. ^{[1
]}

机构：

[1] Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Anal Clin Toxicol Bromatol, Parasitol Lab, BR-14040903 Ribeirao Preto, SP, Brazil

来源：

IMMUNOBIOLOGY | 2010年 / 215卷 / 05期

关键词：

Trypanosoma cruzi; Zinc; DHEA; Peritoneal macrophages; Interferon gamma (IFN-gamma); Nitric oxide (NO); NITRIC-OXIDE; CHAGAS-DISEASE; GAMMA-INTERFERON; IFN-GAMMA; T-CELLS; SYMPATHETIC DENERVATION; INCREASES RESISTANCE; DEHYDROEPIANDROSTERONE; MICE; SUPPLEMENTATION;

D O I：

10.1016/j.imbio.2009.05.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Chagas' disease is considered the sixth most important neglected tropical disease worldwide. Considerable knowledge has been accumulated concerning the role of zinc on cellular immunity. The steroid hormone dehydroepiandrosterone (DHEA) is also known to modulate the immune system. The aims of this paper were to investigate a possible synchronization of their effects on cytokines and NO production and the resistance to Trypanosoma cruzi during the acute phase of infection. It was found that zinc, DHEA or zinc and DHEA supplementation enhanced the immune response, as evidenced by a significant reduction in parasitemia levels. Zinc and DHEA supplementation exerted additive effects on the immune response by elevation of macrophage counts, and by increasing concentrations of IFN-gamma and NO. (C) 2009 Elsevier GmbH. All rights reserved.

引用

页码：427 / 434

页数：8

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