Biochemistry and molecular biology of De Novo Isoprenoid pheromone production in the Scolytidae

被引:87
作者
Seybold, SJ
Tittiger, C
机构
[1] Univ Minnesota, Dept Entomol, St Paul, MN 55108 USA
[2] Univ Minnesota, Dept Forest Resources, St Paul, MN 55108 USA
[3] Univ Nevada, Dept Biochem 330, Reno, NV 89557 USA
关键词
bark beetles; Dendroctonus; gene expression; HMG-CoA reductase; Ips; monoterpenoids;
D O I
10.1146/annurev.ento.48.091801.112645
中图分类号
Q96 [昆虫学];
学科分类号
摘要
Recent application of biochemical and molecular techniques to study the genesis of scolytid aggregation pheromones has revealed that bark beetles are primarily responsible for the endogenous synthesis of widely occurring pheromone components such as ipsenol, ipsdienol, and frontalin. Because many of the chemical signals are isoprenoids, the roles of the mevalonate biosynthetic pathway and the enzyme HMG-CoA reductase (HMG-R) have been investigated. This has led to the identification of endothelial cells in the anterior midgut as the site of synthesis and to the concept that de novo pheromone biosynthesis is regulated in part by the positive effect of juvenile hormone III (JHIII) on gene expression for HMG-R. Both the pronounced regulation by JHIII and the expression pattern of eukaryotic HMG-R argue against synthesis of these pheromones by prokaryotes. As the mevalonate pathway and its regulation have been studied in few other insects, broader issues addressed through the study of scolytid pheromone biosynthesis include major step versus coordinate regulation of the pathway and a genomics approach to elucidating the entire pathway and the mode of action of JHIII.
引用
收藏
页码:425 / 453
页数:31
相关论文
共 166 条
[1]  
ANDERSON RF, 1948, J ECON ENTOMOL, V41, P596, DOI 10.1093/jee/41.4.596
[2]  
[Anonymous], 1985, CGL
[3]  
[Anonymous], COMPREHENSIVE NATURA
[4]   RAT MITOCHONDRIAL AND CYTOSOLIC 3-HYDROXY-3-METHYLGLUTARYL-COA SYNTHASES ARE ENCODED BY 2 DIFFERENT GENES [J].
AYTE, J ;
GILGOMEZ, G ;
HARO, D ;
MARRERO, PF ;
HEGARDT, FG .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (10) :3874-3878
[5]   FIELD RESPONSE TO A NEW PHEROMONAL COMPOUND ISOLATED FROM IPS-TYPOGRAPHUS [J].
BAKKE, A ;
FROYEN, P ;
SKATTEBOL, L .
NATURWISSENSCHAFTEN, 1977, 64 (02) :98-99
[6]  
BARKAWI LS, 2002, THESIS U NEVADA RENO
[7]  
BARKAWI LS, 2002, IN PRESS INSECT BIOC
[8]   ISOPRENOID BIOSYNTHESIS IN ASEPTIC LARVAE OF CALLIPHORA-ERYTHROCEPHALA [J].
BEEDLE, AS ;
WALTON, MJ ;
GOODWIN, TW .
INSECT BIOCHEMISTRY, 1975, 5 (04) :465-472
[9]  
Berciano MT, 2000, GLIA, V29, P246, DOI 10.1002/(SICI)1098-1136(20000201)29:3<246::AID-GLIA6>3.0.CO
[10]  
2-L