Functional magnetic resonance imaging of human brain activation during cue-induced cocaine craving

被引:333
作者
Maas, LC
Lukas, SE
Kaufman, MJ
Weiss, RD
Daniels, SL
Rogers, VW
Kukes, TJ
Renshaw, PF
机构
[1] McLean Hosp, Brain Imaging Ctr, Belmont, MA 02178 USA
[2] Harvard Univ, MIT, Div Hlth Sci & Technol, Boston, MA 02115 USA
[3] Harvard Univ, MIT, Div Hlth Sci & Technol, Cambridge, MA 02139 USA
[4] Harvard Univ, Sch Med, Consolidated Dept Psychiat, Boston, MA USA
[5] McLean Hosp, Alcohol Abuse Res & Treatment Ctr, Belmont, MA 02178 USA
[6] McLean Hosp, Drug Abuse Res & Treatment Ctr, Belmont, MA 02178 USA
关键词
D O I
10.1176/ajp.155.1.124
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Objective: Functional magnetic resonance Imaging (MRI) was used to test whether brain activation was detectable in regions previously associated with cocaine cue-induced craving. Method: Blood oxygenation level dependent (BOLD) functional activation was measured during presentation of audiovisual stimuli containing alternating intervals of drug-related and neutral scenes to six male subjects with a history of crack cocaine use and six male comparison subjects. Results: Significant activation was detected in the anterior cingulate and left dorsolateral prefrontal cortex in the cocaine-using group. In addition, a correlation between self-reported levels of craving and activation in these regions was found. Conclusions: These results suggest that Junctional MRI may be a useful tool to study the neurobiological basis of cue-induced craving.
引用
收藏
页码:124 / 126
页数:3
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