The genetic architecture of resistance

被引:153
作者
Young, ND
机构
[1] Univ Minnesota, Dept Plant Pathol, St Paul, MN 55108 USA
[2] Univ Minnesota, Dept Plant Biol, St Paul, MN 55108 USA
关键词
D O I
10.1016/S1369-5266(00)00081-9
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Plant resistance genes (R genes), especially the nucleotide binding site leucine-rich repeat (NBS-LRR) family of sequences, have been extensively studied in terms of structural organization, sequence evolution and genome distribution. These studies indicate that NBS-LRR sequences can be split into two related groups that have distinct amino-acid motif organizations, evolutionary histories and signal transduction pathways. One NBS-LRR group, characterized by the presence of a Toll/interleukin receptor domain at the aminoterminal end, seems to be absent from the Poaceae. Phylogenetic analysis suggests that a small number of NBS-LRR sequences existed among ancient Angiosperms and that these ancestral sequences diversified after the separation into distinct taxonomic families. There are probably hundreds, perhaps thousands, of NBS-LRR sequences and other types of R gene-like sequences within a typical plant genome. These sequences frequently reside in 'mega-clusters' consisting of smaller clusters with several members each, all localized within a few million base pairs of one another. The organization of R-gene clusters highlights a tension between diversifying and conservative selection that may be relevant to gene families that are unrelated to disease resistance.
引用
收藏
页码:285 / 290
页数:6
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