Lysophosphaticlic acid inhibits serum deprivation-induced autophagy in human prostate cancer PC-3 cells

被引：25

作者：

Chang, Chi-Lun

Liao, Jiaun

Huang, Wei-Pang

Lee, Hsinyu ^{[1
]}

机构：

[1] Natl Taiwan Univ, Dept Life Sci, Taipei 10764, Taiwan

[2] Natl Taiwan Univ, Inst Zool, Taipei 10764, Taiwan

来源：

AUTOPHAGY | 2007年 / 3卷 / 03期

关键词：

LPA; autophagy; PC-3; prostate cancer; S1P; lysophospholipid; LC3;

D O I：

10.4161/auto.3909

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Lysophosphatidic acid (LPA) is a platelet-enriched bioactive lysophospholipid. By binding to its cognitive G protein-coupled receptors, which are encoded by endothelial differentiation genes (edgs), LPA regulates various cellular activities including proliferation, survival, and migration. Currently, little is known about the influences of LPA on autophagy, a pivotal mechanism for cell survival during conditions of starvation. Herein we present data indicating that LPA attenuates starvation-induced autophagy, by monitoring the percentage of LC3-II, an autophagy indicator, in human prostate PC-3 cells. In addition, by using cells stably expressing EGFP-LC3, LPA is shown to inhibit the formation of autophagosomes in serum-starved conditions. Our results suggest that in these conditions, LPA inhibits autophagy, which might facilitate early cancer development.

引用

页码：268 / 270

页数：3

共 26 条

[1] Cell surface receptors in lysophospholipid signaling [J].