In vitro activity of the histatin derivative P-113 against multidrug-resistant pathogens responsible for pneumonia in immunocompromised patients

被引：27

作者：

Giacometti, A

Cirioni, O

Kamysz, W

D'Amato, G

Silvestri, C

Del Prete, MS

Licci, A

Riva, A

Lukasiak, J

Scalise, G

机构：

[1] Univ Politecn Marche, Inst Infect Dis & Publ Hlth, Ancona, Italy

[2] Med Univ Gdansk, Fac Pharm, Gdansk, Poland

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2005年 / 49卷 / 03期

关键词：

D O I：

10.1128/AAC.49.3.1249-1252.2005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The in vitro activity of the histatin derivative P-113, alone or combined with eight antibiotics, was investigated against multidrug-resistant strains isolated from clinical specimens of immunocompromised patients with pneumonia. The gram-negative isolates were susceptible to P-113. S. aureus showed less susceptibility. Synergy was demonstrated when P-113 was combined with beta-lactams against gram-negative organisms.

引用

页码：1249 / 1252

页数：4

共 22 条

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