Does the MTHFR 677T allele alter the clinical phenotype in severe haemophilia A?

被引：18

作者：

Ahmed, R ^{[1
]}

Kannan, M ^{[1
]}

Choudhry, VP ^{[1
]}

Saxena, R ^{[1
]}

机构：

[1] All India Inst Med Sci, Dept Haematol, New Delhi 110029, India

来源：

THROMBOSIS RESEARCH | 2003年 / 109卷 / 01期

关键词：

haemophilia a; factor V Leiden; prothrombin G20210A; methylene tetrahydrofolate reductase C677T;

D O I：

10.1016/S0049-3848(03)00144-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：71 / 72

页数：2

共 9 条

[1]

AHMED R, 2003, IN PRESS THROMB RES

[2]

ARBINI AA, 1995, THROMB HAEMOSTASIS, V74, P1255

[3] HIGH PREVALENCE OF A MUTATION IN THE FACTOR-V GENE WITHIN THE UK POPULATION - RELATIONSHIP TO ACTIVATED PROTEIN-C RESISTANCE AND FAMILIAL THROMBOSIS [J].

BEAUCHAMP, NJ ;

DALY, ME ;

HAMPTON, KK ;

COOPER, PC ;

PRESTON, FE ;

PEAKE, IR .

BRITISH JOURNAL OF HAEMATOLOGY, 1994, 88 (01) :219-222

[4]

DACIE JV, PRACTICAL HAEMATOLOG, P341

[5]

Ettingshausen CE, 2001, THROMB HAEMOSTASIS, V85, P218

[6] A CANDIDATE GENETIC RISK FACTOR FOR VASCULAR-DISEASE - A COMMON MUTATION IN METHYLENETETRAHYDROFOLATE REDUCTASE [J].

FROSST, P ;

BLOM, HJ ;

MILOS, R ;

GOYETTE, P ;

SHEPPARD, CA ;

MATTHEWS, RG ;

BOERS, GJH ;

DENHEIJER, M ;

KLUIJTMANS, LAJ ;

VANDENHEUVEL, LP ;

ROZEN, R .

NATURE GENETICS, 1995, 10 (01) :111-113

[7] HEMOPHILIA-A [J].

HOYER, LW .

NEW ENGLAND JOURNAL OF MEDICINE, 1994, 330 (01) :38-47

[8]

Lee DH, 2000, THROMB HAEMOSTASIS, V83, P387

[9] A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis [J].

Poort, SR ;

Rosendaal, FR ;

Reitsma, PH ;

Bertina, RM .

BLOOD, 1996, 88 (10) :3698-3703

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