Synthesis of a six-carbon sialic acid using an indium-mediated coupling

被引：44

作者：

Chappell, MD ^{[1
]}

Halcomb, RL ^{[1
]}

机构：

[1] Univ Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 14期

关键词：

D O I：

10.1021/ol990320r

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

GRAPHICS The synthesis of a six carbon truncated sialic acid is described, A key step in the synthesis was an indium mediated allyl addition to a serine derived aldehyde, Careful choice of protecting groups was found to be necessary in order to prevent unwanted side reactions throughout the sequence, The truncated sialic acid was obtained in a form suitable for activation as a glycosyl donor.

引用

页码：2003 / 2005

页数：3

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