The polymerization motor

被引：122

作者：

Theriot, JA ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Biochem, Stanford, CA 94305 USA

[2] Stanford Univ, Sch Med, Dept Microbiol & Immunol, Stanford, CA 94305 USA

来源：

TRAFFIC | 2000年 / 1卷 / 01期

关键词：

actin; Brownian ratchet; force generation; microtubule; protein polymerization;

D O I：

10.1034/j.1600-0854.2000.010104.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Polymerization and depolymerization of actin filaments and microtubules are thought to generate force for movement in various kinds of cell motility, ranging from lamellipodial protrusion to chromosome segregation. This article reviews the thermodynamic and physical theories of how a nonequilibrium polymerization reaction can be used to transduce chemical energy into mechanical energy, and summarizes the evidence suggesting that actin polymerization produces motile force in several biological systems.

引用

页码：19 / 28

页数：10

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