Hedgehog signalling: How cholesterol modulates the signal

被引：26

作者：

Ingham, PW ^{[1
]}

机构：

[1] Univ Sheffield, Krebs Inst, MRC, Intercellular Signalling Grp,Dev Genet Programme, Sheffield S10 2TN, S Yorkshire, England

来源：

CURRENT BIOLOGY | 2000年 / 10卷 / 05期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

D O I：

10.1016/S0960-9822(00)00346-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

By coupling to cholesterol, Hedgehog can be anchored to the cells where it is made, yet to act as a morphogen, it must be able to move away from its source. Novel genes have now been identified that control the release and dispersal of Hedgehog, shedding new light on the part played by cholesterol in these processes.

引用

收藏

页码：R180 / R183

页数：4

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