The final touches make perfect the peptide-MHC class I repertoire

被引：80

作者：

Hammer, Gianna Elena ^{[1
]}

Kanaseki, Takayuki ^{[1
]}

Shastri, Nilabh ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Mol & Cell Biol, Div Immunol, Berkeley, CA 94720 USA

来源：

IMMUNITY | 2007年 / 26卷 / 04期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/j.immuni.2007.04.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Major histocompatibility complex (MHC) class I molecules present short, perfectly cleaved peptides on the cell surface for immune surveillance by CD8(+) T cells. The pathway for generating these peptides begins in the cytoplasm, and the peptide-MHC I (pMHC I) repertoire is finalized in the endoplasmic reticulum. Recent studies show that the peptides for MHC I are customized by the ER aminopeptidase associated with antigen processing and by dynamic interactions within the MHC peptide-loading complex. Failure to customize the pMHC I repertoire has profound immunological consequences.

引用

页码：397 / 406

页数：10

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