The use of pre- pro- and synbiotics in adult intensive care unit patients: Systematic review

被引:58
作者
Watkinson, Peter J. [1 ]
Barber, Vicki S.
Dark, Paul
Young, J. Duncan
机构
[1] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Anaesthet, Intens Care Soc Trials Grp,Kadoorie Ctr, Oxford OX3 9DU, England
[2] Univ Manchester, Hope Hosp, Manchester M13 9PL, Lancs, England
关键词
systematic review; meta-anatysis; nutrition; prevention; pneumonia; probiotic;
D O I
10.1016/j.clnu.2006.07.010
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Background & Aims: This review investigated whether the administration of enteral pre-, pro- and synbiotics compared with controls in adult intensive care unit (ICU) patients reduced the incidence of nosocomial infections, length of ICU stay, hospital mortality and specifically pneumonia. Methods: Systematic review of randomised controlled trials comparing enteral feeding and pre-, pro- or synbiotics, versus standard enteral feed alone, in patients admitted to adult ICUs. Results: Eight randomised studies with a total of 999 critically ill adult patients met the inclusion criteria. Pre- pro- or synbiotics were not associated with any significant change in the outcomes studied-length of ICU stay, hospital mortality and the incidence of nosocomial infection and more specifically pneumonia incidence. Few data were available for other outcomes. Conclusions: The use of pre- pro- or synbiotics in adult critically ill patients confers no statistically significant benefit in the outcome criteria studied. There is currently a lack of evidence to support the use of pre- pro- or synbiotics in patients admitted to adult ICUs, and a large well-designed trial is needed in this area. (c) 2006 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
引用
收藏
页码:182 / 192
页数:11
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