Bone morphogenetic proteins in destructive and remodeling arthritis

被引：43

作者：

Lories, Rik J. U. ^{[1
]}

Luyten, Frank P. ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Dept Musculoskeletal Sci, Div Rheumatol, Lab Skeletal Dev & Joint Disorders, B-3000 Louvain, Belgium

来源：

ARTHRITIS RESEARCH & THERAPY | 2007年 / 9卷 / 02期

关键词：

D O I：

10.1186/ar2135

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Joint destruction and tissue responses determine the outcome of chronic arthritis. Joint inflammation and damage are often the dominant clinical presentation. However, in some arthritic diseases, in particular the spondyloarthritides, joint remodeling is a prominent feature, with new cartilage and bone formation leading to ankylosis and contributing to loss of function. A role for bone morphogenetic proteins in joint remodeling has been demonstrated in the formation of both enthesophytes and osteophytes. Data from genetic models support a role for bone morphogenetic protein signaling in cartilage homeostasis. Finally, this signaling pathway is likely to play a steering role in the synovium.

引用

收藏

页数：7

相关论文

共 51 条

[1]

Extracellular regulation of BMP signaling in vertebrates: A cocktail of modulators [J].

Balemans, W ;

Van Hul, W .

DEVELOPMENTAL BIOLOGY, 2002, 250 (02) :231-250

[2]

Synovial lining macrophages mediate osteophyte formation during experimental osteoarthritis [J].

Blom, AB ;

van Lent, PLEM ;

Holthuysen, AEM ;

van der Kraan, PM ;

Roth, J ;

van Rooijen, N ;

van den Berg, WB .

OSTEOARTHRITIS AND CARTILAGE, 2004, 12 (08) :627-635

[3]

Decrease in expression of bone morphogenetic proteins 4 and 5 in synovial tissue of patients with osteoarthritis and rheumatoid arthritis [J].

Bramlage, Carsten P. ;

Haupl, Thomas ;

Kaps, Christian ;

Ungethum, Ute ;

Krenn, Veit ;

Pruss, Axel ;

Muller, Gerhard A. ;

Strutz, Frank ;

Burmester, Gerd-R .

ARTHRITIS RESEARCH & THERAPY, 2006, 8 (03)

[4]

Defining a robe for fibroblasts in the persistence of chronic inflammatory joint disease [J].

Buckley, CD ;

Filer, A ;

Haworth, O ;

Parsonage, G ;

Salmon, M .

ANNALS OF THE RHEUMATIC DISEASES, 2004, 63 :92-95

[5]

Articular cartilage injuries [J].

Buckwalter, JA .

CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, 2002, (402) :21-37

[6]

Mesenchymal precursor cells [J].

Corr, M ;

Zvaifler, NJ .

ANNALS OF THE RHEUMATIC DISEASES, 2002, 61 (01) :3-5

[7]

Expression of transforming growth factor-β (TGFβ) and the TGFβ signalling molecule SMAD-2P in spontaneous and instability-induced osteoarthritis:: role in cartilage degradation, chondrogenesis and osteophyte formation [J].

Davidson, E. N. Blaney ;

Vitters, E. L. ;

van der Kraan, P. M. ;

van den Berg, W. B. .

ANNALS OF THE RHEUMATIC DISEASES, 2006, 65 (11) :1414-1421

[8]

De Bari C, 2001, ARTHRITIS RHEUM-US, V44, P1928, DOI 10.1002/1529-0131(200108)44:8<1928::AID-ART331>3.0.CO

[9]

2-P

[10]

de Vlam Kurt, 2006, Curr Rheumatol Rep, V8, P332

← 1 2 3 4 5 6 →