rum1: A CDK inhibitor regulating G1 progression in fission yeast

被引：17

作者：

Labib, K ^{[1
]}

Moreno, S ^{[1
]}

机构：

[1] UNIV SALAMANCA,CSIC,INST MICROBIOL BIOQUIM,DEPT GENET & MICROBIOL,E-37007 SALAMANCA,SPAIN

来源：

TRENDS IN CELL BIOLOGY | 1996年 / 6卷 / 02期

关键词：

D O I：

10.1016/0962-8924(96)81016-6

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In all eukaryotes, entry into mitosis from G2 phase is initiated by a complex of the cdc2 kinase and a B-type cyclin. It has now been shown that, in fission yeast, B-type cyclins also activate cdc2 in G1, thus governing cell-cycle commitment, as well as the onset of S phase. In this article, Karim Labib and Sergio Moreno review the evidence that rum1 inhibits the kinase activity of cdc2 associated with B-type cyclins and is an important regulator of G1 progression in fission yeast.

引用

页码：62 / 66

页数：5

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