Semaphorins: Mediators of repulsive growth cone guidance

被引：91

作者：

Kolodkin, AL

机构：

[1] Dept of Neuroscience, Johns Hopkins Univ. Sch. of Med., Baltimore, MD 21205

来源：

TRENDS IN CELL BIOLOGY | 1996年 / 6卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0962-8924(96)81033-6

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

During development, neuronal growth cones encounter a variety of guidance cues while mediating axon pathfinding, target recognition and synapse formation. It is clear that repulsive guidance mechanisms play an essential role in these processes. The semaphorin gene family, which is conserved from invertebrates to mammals, includes members that mediate repulsive guidance. Molecular and cellular analysis of this gene family is providing insight into how inhibitory cues function during neurodevelopment.

引用

页码：15 / 22

页数：8

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