共 61 条
A proteasome for all occasions
被引:137
作者:

Hanna, John
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Finley, Daniel
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h-index: 0
机构:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA
机构:
[1] Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA
关键词:
ubiquitin;
proteasome;
stress;
Rpn4;
AIRAP;
Ubp6;
D O I:
10.1016/j.febslet.2007.03.053
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
In the ubiquitin-proteasome system, substrates fated for destruction first acquire covalent modification by ubiquitin, and are subsequently destroyed by the proteasome. Traditionally, 26S proteasomes have been seen as largely uniform in their composition and functional capacity. Accordingly, cells can control proteasome abundance via transcriptional pathways that mediate concerted regulation of all known proteasome genes. However, recent evidence suggests that the proteasome is also subject to subunit-specific modes of regulation, which serve to alter proteasome function and may generate ensembles of compositionally distinct proteasomes. These modes of proteasome regulation provide varied means to adapt protein degradation pathways to changing conditions in the cell. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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页码:2854 / 2861
页数:8
相关论文
共 61 条
[1]
The base of the proteasome regulatory particle exhibits chaperone-like activity
[J].
Braun, BC
;
Glickman, M
;
Kraft, R
;
Dahlmann, B
;
Kloetzel, PM
;
Finley, D
;
Schmidt, M
.
NATURE CELL BIOLOGY,
1999, 1 (04)
:221-226

Braun, BC
论文数: 0 引用数: 0
h-index: 0
机构: Humboldt Univ, Inst Biochem, Fak Med, D-10117 Berlin, Germany

Glickman, M
论文数: 0 引用数: 0
h-index: 0
机构: Humboldt Univ, Inst Biochem, Fak Med, D-10117 Berlin, Germany

Kraft, R
论文数: 0 引用数: 0
h-index: 0
机构: Humboldt Univ, Inst Biochem, Fak Med, D-10117 Berlin, Germany

Dahlmann, B
论文数: 0 引用数: 0
h-index: 0
机构: Humboldt Univ, Inst Biochem, Fak Med, D-10117 Berlin, Germany

Kloetzel, PM
论文数: 0 引用数: 0
h-index: 0
机构: Humboldt Univ, Inst Biochem, Fak Med, D-10117 Berlin, Germany

Finley, D
论文数: 0 引用数: 0
h-index: 0
机构: Humboldt Univ, Inst Biochem, Fak Med, D-10117 Berlin, Germany

Schmidt, M
论文数: 0 引用数: 0
h-index: 0
机构: Humboldt Univ, Inst Biochem, Fak Med, D-10117 Berlin, Germany
[2]
A MULTIUBIQUITIN CHAIN IS CONFINED TO SPECIFIC LYSINE IN A TARGETED SHORT-LIVED PROTEIN
[J].
CHAU, V
;
TOBIAS, JW
;
BACHMAIR, A
;
MARRIOTT, D
;
ECKER, DJ
;
GONDA, DK
;
VARSHAVSKY, A
.
SCIENCE,
1989, 243 (4898)
:1576-1583

CHAU, V
论文数: 0 引用数: 0
h-index: 0
机构: MIT,DEPT BIOL,CAMBRIDGE,MA 02139

TOBIAS, JW
论文数: 0 引用数: 0
h-index: 0
机构: MIT,DEPT BIOL,CAMBRIDGE,MA 02139

BACHMAIR, A
论文数: 0 引用数: 0
h-index: 0
机构: MIT,DEPT BIOL,CAMBRIDGE,MA 02139

MARRIOTT, D
论文数: 0 引用数: 0
h-index: 0
机构: MIT,DEPT BIOL,CAMBRIDGE,MA 02139

ECKER, DJ
论文数: 0 引用数: 0
h-index: 0
机构: MIT,DEPT BIOL,CAMBRIDGE,MA 02139

GONDA, DK
论文数: 0 引用数: 0
h-index: 0
机构: MIT,DEPT BIOL,CAMBRIDGE,MA 02139

VARSHAVSKY, A
论文数: 0 引用数: 0
h-index: 0
机构: MIT,DEPT BIOL,CAMBRIDGE,MA 02139
[3]
Pleiotropic effects of Ubp6 loss on drug sensitivities and yeast prion are due to depletion of the free ubiquitin pool
[J].
Chernova, TA
;
Allen, KD
;
Wesoloski, LM
;
Shanks, JR
;
Chernoff, YO
;
Wilkinson, KD
.
JOURNAL OF BIOLOGICAL CHEMISTRY,
2003, 278 (52)
:52102-52115

Chernova, TA
论文数: 0 引用数: 0
h-index: 0
机构: Emory Univ, Sch Med, Dept Biochem, Atlanta, GA 30322 USA

Allen, KD
论文数: 0 引用数: 0
h-index: 0
机构: Emory Univ, Sch Med, Dept Biochem, Atlanta, GA 30322 USA

Wesoloski, LM
论文数: 0 引用数: 0
h-index: 0
机构: Emory Univ, Sch Med, Dept Biochem, Atlanta, GA 30322 USA

Shanks, JR
论文数: 0 引用数: 0
h-index: 0
机构: Emory Univ, Sch Med, Dept Biochem, Atlanta, GA 30322 USA

Chernoff, YO
论文数: 0 引用数: 0
h-index: 0
机构: Emory Univ, Sch Med, Dept Biochem, Atlanta, GA 30322 USA

Wilkinson, KD
论文数: 0 引用数: 0
h-index: 0
机构: Emory Univ, Sch Med, Dept Biochem, Atlanta, GA 30322 USA
[4]
Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1
[J].
Cope, GA
;
Suh, GSB
;
Aravind, L
;
Schwarz, SE
;
Zipursky, SL
;
Koonin, EV
;
Deshaies, RJ
.
SCIENCE,
2002, 298 (5593)
:608-611

Cope, GA
论文数: 0 引用数: 0
h-index: 0
机构: CALTECH, Dept Biol, Pasadena, CA 91125 USA

Suh, GSB
论文数: 0 引用数: 0
h-index: 0
机构: CALTECH, Dept Biol, Pasadena, CA 91125 USA

Aravind, L
论文数: 0 引用数: 0
h-index: 0
机构: CALTECH, Dept Biol, Pasadena, CA 91125 USA

Schwarz, SE
论文数: 0 引用数: 0
h-index: 0
机构: CALTECH, Dept Biol, Pasadena, CA 91125 USA

Zipursky, SL
论文数: 0 引用数: 0
h-index: 0
机构: CALTECH, Dept Biol, Pasadena, CA 91125 USA

Koonin, EV
论文数: 0 引用数: 0
h-index: 0
机构: CALTECH, Dept Biol, Pasadena, CA 91125 USA

Deshaies, RJ
论文数: 0 引用数: 0
h-index: 0
机构:
CALTECH, Dept Biol, Pasadena, CA 91125 USA CALTECH, Dept Biol, Pasadena, CA 91125 USA
[5]
Ubiquitin chains are remodeled at the proteasome by opposing ubiquitin ligase and deubiquitinating activities
[J].
Crosas, Bernat
;
Hanna, John
;
Kirkpatrick, Donald S.
;
Zhang, Dan Phoebe
;
Tone, Yoshiko
;
Hathaway, Nathaniel A.
;
Buecker, Christa
;
Leggett, David S.
;
Schmidt, Marion
;
King, Randall W.
;
Gygi, Steven P.
;
Finley, Daniel
.
CELL,
2006, 127 (07)
:1401-1413

Crosas, Bernat
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Hanna, John
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Kirkpatrick, Donald S.
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Zhang, Dan Phoebe
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Tone, Yoshiko
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Hathaway, Nathaniel A.
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Buecker, Christa
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Leggett, David S.
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Schmidt, Marion
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

King, Randall W.
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Gygi, Steven P.
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Finley, Daniel
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA
[6]
Proteasome subunit Rpn1 binds ubiquitin-like protein domains
[J].
Elsasser, S
;
Gali, RR
;
Schwickart, M
;
Larsen, CN
;
Leggett, DS
;
Müller, B
;
Feng, MT
;
Tübing, F
;
Dittmar, GAG
;
Finley, D
.
NATURE CELL BIOLOGY,
2002, 4 (09)
:725-730

论文数: 引用数:
h-index:
机构:

Gali, RR
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Schwickart, M
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Larsen, CN
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Leggett, DS
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Müller, B
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Feng, MT
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Tübing, F
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Dittmar, GAG
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Finley, D
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA
[7]
Rad23 and Rpn10 serve as alternative ubiquitin receptors for the proteasome
[J].
Elsasser, S
;
Chandler-Militello, D
;
Müller, B
;
Hanna, J
;
Finley, D
.
JOURNAL OF BIOLOGICAL CHEMISTRY,
2004, 279 (26)
:26817-26822

论文数: 引用数:
h-index:
机构:

Chandler-Militello, D
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Müller, B
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Hanna, J
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Finley, D
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA
[8]
Unified nomenclature for subunits of the Saccharomyces cerevisiae proteasome regulatory particle
[J].
Finley, D
;
Tanaka, K
;
Mann, C
;
Feldmann, H
;
Hochstrasser, M
;
Vierstra, R
;
Johnston, S
;
Hampton, R
;
Haber, J
;
McCusker, J
;
Silver, P
;
Frontali, L
;
Thorsness, P
;
Varshavsky, A
;
Byers, B
;
Madura, K
;
Reed, SI
;
Wolf, D
;
Jentsch, S
;
Sommer, T
;
Baumeister, W
;
Goldberg, A
;
Fried, V
;
Rubin, DM
;
Glickman, MH
;
Toh-E, A
.
TRENDS IN BIOCHEMICAL SCIENCES,
1998, 23 (07)
:244-245

Finley, D
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Tanaka, K
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Mann, C
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Feldmann, H
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Hochstrasser, M
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Vierstra, R
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Johnston, S
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Hampton, R
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Haber, J
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

McCusker, J
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Silver, P
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Frontali, L
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Thorsness, P
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Varshavsky, A
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Byers, B
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Madura, K
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Reed, SI
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Wolf, D
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Jentsch, S
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Sommer, T
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Baumeister, W
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Goldberg, A
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Fried, V
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Rubin, DM
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Glickman, MH
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Toh-E, A
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA
[9]
Son1p is a component of the 26S proteasome of the yeast Saccharomyces cerevisiae
[J].
Fujimuro, M
;
Tanaka, K
;
Yokosawa, H
;
Toh-e, A
.
FEBS LETTERS,
1998, 423 (02)
:149-154

Fujimuro, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tokyo, Grad Sch Sci, Dept Biol Sci, Tokyo 1130033, Japan

Tanaka, K
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tokyo, Grad Sch Sci, Dept Biol Sci, Tokyo 1130033, Japan

Yokosawa, H
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tokyo, Grad Sch Sci, Dept Biol Sci, Tokyo 1130033, Japan

Toh-e, A
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Tokyo, Grad Sch Sci, Dept Biol Sci, Tokyo 1130033, Japan Univ Tokyo, Grad Sch Sci, Dept Biol Sci, Tokyo 1130033, Japan
[10]
A subcomplex of the proteasome regulatory particle required for ubiquitin-conjugate degradation and related to the COP9-signalosome and eIF3
[J].
Glickman, MH
;
Rubin, DM
;
Coux, O
;
Wefes, I
;
Pfeifer, G
;
Cjeka, Z
;
Baumeister, W
;
Fried, VA
;
Finley, D
.
CELL,
1998, 94 (05)
:615-623

Glickman, MH
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Rubin, DM
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Coux, O
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Wefes, I
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Pfeifer, G
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Cjeka, Z
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Baumeister, W
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Fried, VA
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Finley, D
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA